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Science 1 April 1983:
Vol. 220. no. 4592, pp. 81 - 82
DOI: 10.1126/science.6402820
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Articles

Science, Vol 220, Issue 4592, 81-82
Copyright © 1983 by American Association for the Advancement of Science

articles

Normalization of depressed heart function in rats by ribose

HG Zimmer

Severe constriction of the abdominal aorta and simultaneous injection of isoproterenol in rats induced depression in heart function and reductions in cardiac adenosine triphosphate and total adenine nucleotides. When ribose was continuously infused for 24 hours, biosynthesis of cardiac adenine nucleotides was stimulated to such an extent that the reductions in adenosine triphosphate and total adenine nucleotides were prevented and left ventricular hemodynamic parameters were normal. These results support the hypothesis that adenosine triphosphate is primarily responsible for depression in myocardial contractility and that ribose is cardioprotective through its pronounced effects on adenine nucleotide metabolism in heart muscle.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Preservation of diastolic function in monocrotaline-induced right ventricular hypertrophy in rats.
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D-Ribose improves diastolic function and quality of life in congestive heart failure patients: a prospective feasibility study.
H. Omran, S. Illien, D. MacCarter, J. St. Cyr, and B. Luderitz (2003)
Eur J Heart Fail 5, 615-619
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[5-3H]glucose overestimates glycolytic flux in isolated working rat heart: role of the pentose phosphate pathway.
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Am J Physiol Endocrinol Metab 280, E502-E508
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D-Ribose as a Supplement for Cardiac Energy Metabolism.
D. F. Pauly and C. J. Pepine (2000)
Journal of Cardiovascular Pharmacology and Therapeutics 5, 249-258
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Ribose intervention in the cardiac pentose phosphate pathway is not species-specific.
H. Zimmer, H Ibel, U Suchner, and H Schad (1984)
Science 223, 712-714
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