Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 1 April 1983:
Vol. 220. no. 4592, pp. 77 - 79
DOI: 10.1126/science.6338593
Prev | Table of Contents | Next

Articles

Science, Vol 220, Issue 4592, 77-79
Copyright © 1983 by American Association for the Advancement of Science

articles

Insulin-like growth factors: a role in growth hormone negative feedback and body weight regulation via brain

GS Tannenbaum, HJ Guyda, and BI Posner

Intracerebroventricular administration of ILA's, a preparation enriched in insulin-like growth factors, caused a marked decrease in growth hormone secretory episodes and in body weight associated with reduced food intake over 24 hours. Central injection of insulin and bovine serum albumin had no such effects. These findings suggest that insulin-like growth factors play a role in growth hormone negative feedback and body weight regulation at the level of the central nervous system.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
IGF-1 in the Brain as a Regulator of Reproductive Neuroendocrine Function.
S. S. Daftary and A. C. Gore (2005)
Experimental Biology and Medicine 230, 292-306
   Abstract »    Full Text »    PDF »
Increased Plasma Levels of Insulin-Like Growth Factor 2 and Insulin-Like Growth Factor Binding Protein 3 Are Associated with Endometrial Cancer Risk.
J. C. Oh, W. Wu, G. Tortolero-Luna, R. Broaddus, D. M. Gershenson, T. W. Burke, R. Schmandt, and K. H. Lu (2004)
Cancer Epidemiol. Biomarkers Prev. 13, 748-752
   Abstract »    Full Text »    PDF »
A Novel Missense Mutation in the Mouse Growth Hormone Gene Causes Semidominant Dwarfism, Hyperghrelinemia, and Obesity.
C. W. E. Meyer, D. Korthaus, W. Jagla, E. Cornali, J. Grosse, H. Fuchs, M. Klingenspor, S. Roemheld, M. Tschop, G. Heldmaier, et al. (2004)
Endocrinology 145, 2531-2541
   Abstract »    Full Text »    PDF »
Low Circulating IGF-II Concentrations Predict Weight Gain and Obesity in Humans.
M. S. Sandhu, J. M. Gibson, A. H. Heald, D. B. Dunger, and N. J. Wareham (2003)
Diabetes 52, 1403-1408
   Abstract »    Full Text »    PDF »
IGF-I does not affect the net increase in GH release in response to arginine.
R. Nass, S. S. Pezzoli, I. M. Chapman, J. Patrie, R. L. Hintz, M. L. Hartman, and M. O. Thorner (2002)
Am J Physiol Endocrinol Metab 283, E702-E710
   Abstract »    Full Text »    PDF »
Characterization of pituitary IGF-I receptors: modulation of prolactin and growth hormone.
S. Fruchtman, D. C. McVey, and R. J. Borski (2002)
Am J Physiol Regulatory Integrative Comp Physiol 283, R468-R476
   Abstract »    Full Text »    PDF »
Liver-Derived IGF-I Regulates GH Secretion at the Pituitary Level in Mice.
K. Wallenius, K. Sjogren, X.-D. Peng, S. Park, V. Wallenius, J.-L. Liu, M. Umaerus, H. Wennbo, O. Isaksson, L. Frohman, et al. (2001)
Endocrinology 142, 4762-4770
   Abstract »    Full Text »    PDF »
IGF-I Treatment Reduces Hyperphagia, Obesity, and Hypertension in Metabolic Disorders Induced by Fetal Programming.
M. H. Vickers, B. A. Ikenasio, and B. H. Breier (2001)
Endocrinology 142, 3964-3973
   Abstract »    Full Text »    PDF »
Deletion of a nuclease-sensitive region between the Igf2 and H19 genes leads to Igf2 misregulation and increased adiposity.
B. K. Jones, J. Levorse, and S. M. Tilghman (2001)
Hum. Mol. Genet. 10, 807-814
   Abstract »    Full Text »    PDF »
Insulin-Like Growth Factor-1 Regulation of {{alpha}}1-Adrenergic Receptor Signaling Is Estradiol Dependent in the Preoptic Area and Hypothalamus of Female Rats.
A. Quesada and A. M. Etgen (2001)
Endocrinology 142, 599-607
   Abstract »    Full Text »    PDF »
Effects of Recombinant Human Insulin-Like Growth Factor I Administration on the Growth Hormone (GH) Response to GH-Releasing Hormone in Obesity.
M. Maccario, F. Tassone, L. Gianotti, F. Lanfranco, S. Grottoli, E. Arvat, E. E. Muller, and E. Ghigo (2001)
J. Clin. Endocrinol. Metab. 86, 167-171
   Abstract »    Full Text »
Serum C-Peptide, Insulin-Like Growth Factor (IGF)-I, IGF-Binding Proteins, and Colorectal Cancer Risk in Women.
R. Kaaks, P. Toniolo, A. Akhmedkhanov, A. Lukanova, C. Biessy, H. Dechaud, S. Rinaldi, A. Zeleniuch-Jacquotte, R. E. Shore, and E. Riboli (2000)
J Natl Cancer Inst 92, 1592-1600
   Abstract »    Full Text »    PDF »
Arginine Counteracts the Inhibitory Effect of Recombinant Human Insulin-Like Growth Factor I on the Somatotroph Responsiveness to Growth Hormone-Releasing Hormone in Humans.
L. Gianotti, M. Maccario, F. Lanfranco, J. Ramunni, L. Di Vito, S. Grottoli, E. E. Muller, E. Ghigo, and E. Arvat (2000)
J. Clin. Endocrinol. Metab. 85, 3604-3608
   Abstract »    Full Text »
Effects of Recombinant Human Insulin-Like Growth Factor I Administration on Spontaneous and Growth Hormone (GH)-Releasing Hormone-Stimulated GH Secretion in Anorexia Nervosa.
L. Gianotti, A. I. Pincelli, M. Scacchi, M. Rolla, D. Bellitti, E. Arvat, F. Lanfranco, A. Torsello, E. Ghigo, F. Cavagnini, et al. (2000)
J. Clin. Endocrinol. Metab. 85, 2805-2809
   Abstract »    Full Text »
Insulin-Like Growth Factor I Disparately Regulates Prolactin and Growth Hormone Synthesis and Secretion: Studies Using the Teleost Pituitary Model.
S. Fruchtman, L. Jackson, and R. Borski (2000)
Endocrinology 141, 2886-2894
   Abstract »    Full Text »    PDF »
Insulin-Like Growth Factor I Is Essential for Postnatal Growth in Response to Growth Hormone.
J.-L. Liu and D. LeRoith (1999)
Endocrinology 140, 5178-5184
   Abstract »    Full Text »
Editorial: Insulin-Like Growth Factor I--A Prototypic Peripheral-Paracrine Hormone?.
S. Melmed (1999)
Endocrinology 140, 3879-3880
   Full Text »
Neuroendocrine Control of Growth Hormone Secretion.
E. E. Muller, V. Locatelli, and D. Cocchi (1999)
Physiol Rev 79, 511-607
   Abstract »    Full Text »    PDF »
Effects of Recombinant Human Insulin-Like Growth Factor I Administration on Growth Hormone (GH) Secretion, Both Spontaneous and Stimulated by GH-Releasing Hormone or Hexarelin, a Peptidyl GH Secretagogue, in Humans.
E. Ghigo, L. Gianotti, E. Arvat, J. Ramunni, M. R. Valetto, F. Broglio, M. Rolla, F. Cavagnini, and E. E. Müller (1999)
J. Clin. Endocrinol. Metab. 84, 285-290
   Abstract »    Full Text »
Molecular Mechanisms of the Negative Effect of Insulin-Like Growth Factor-I on Growth Hormone Gene Expression in MtT/S Somatotroph Cells.
A. Niiori-Onishi, Y. Iwasaki, N. Mutsuga, Y. Oiso, K. Inoue, and H. Saito (1999)
Endocrinology 140, 344-349
   Abstract »    Full Text »
Pathophysiology of the Neuroregulation of Growth Hormone Secretion in Experimental Animals and the Human.
A. Giustina and J. D. Veldhuis (1998)
Endocr. Rev. 19, 717-797
   Abstract »    Full Text »
Regulation of the Growth Hormone-Insulin-Like Growth Factor I Axis in Developing and Adult Monkeys Is Affected by Estradiol Replacement and Supplementation with Insulin-Like Growth Factor I.
M. E. Wilson (1998)
J. Clin. Endocrinol. Metab. 83, 2018-2028
   Abstract »    Full Text »
Regulation of Growth Hormone (GH) Gene Expression and Secretion During Pregnancy and Lactation in the Rat: Role of Insulin-Like Growth Factor-I, Somatostatin, and GH-Releasing Hormone.
J. Escalada, F. Sanchez-Franco, B. Velasco, and L. Cacicedo (1997)
Endocrinology 138, 3435-3443
   Abstract »    Full Text »    PDF »
Pituitary Cytokine and Growth Factor Expression and Action.
D. Ray and S. Melmed (1997)
Endocr. Rev. 18, 206-228
   Abstract »    Full Text »
Insulin-Like Growth Factor-I in Human Malnutrition: Relationship with Some Body Composition and Nutritional Parameters.
F. Minuto, A. Barreca, G. F. Adami, P. Fortini, P. Del Monte, F. Cella, N. Scopinaro, and G. Giordano (1989)
JPEN J Parenter Enteral Nutr 13, 392-396
   Abstract »    PDF »
Pituitary Tumors Secreting Growth Hormone and Prolactin.
S. MELMED, G. D. BRAUNSTEIN, J. R. CHANG, and D. P. BECKER (1986)
Ann Intern Med 105, 238-253
   Abstract »    PDF »
Growth hormone-releasing factor: direct effects on growth hormone, glucose, and behavior via the brain.
G. Tannenbaum (1984)
Science 226, 464-466
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)