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Science 1 April 1983:
Vol. 220. no. 4592, pp. 73 - 75
DOI: 10.1126/science.6402819
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Articles

Science, Vol 220, Issue 4592, 73-75
Copyright © 1983 by American Association for the Advancement of Science

articles

Blood cell surface changes in Drosophila mutants with melanotic tumors

TM Rizki and RM Rizki

When wheat germ agglutinin conjugated to fluorescein isothiocyanate is bound to hemocytes from larvae of Drosophila melanogaster, two populations of hemocytes are distinguished. One shows a fluorescent speckled surface (spk+) and the other lacks this characteristic (spk-). In mutant larvae with melanotic tumors and in larval hosts with heterospecific implants, most of the lamellocytes (a hemocyte variant involved in capsule formation and tissue rejection) are spk+, whereas the lamellocytes in nontumorous larvae are spk-. This suggests that spk+ lamellocytes are necessary for encapsulation of aberrant tissues in the mutant larvae and are responsible for rejection of foreign tissue implants.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Melanotic Mutants in Drosophila: Pathways and Phenotypes.
S. Minakhina and R. Steward (2006)
Genetics 174, 253-263
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Fluorescence-activated cell sorting (FACS) of Drosophila hemocytes reveals important functional similarities to mammalian leukocytes.
R. Tirouvanziam, C. J. Davidson, J. S. Lipsick, and L. A. Herzenberg (2004)
PNAS 101, 2912-2917
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Helix pomatia Lectin, an Inducer of Drosophila Immune Response, Binds to Hemomucin, a Novel Surface Mucin.
U. Theopold, C. Samakovlis, H. Erdjument-Bromage, N. Dillon, B. Axelsson, O. Schmidt, P. Tempst, and D. Hultmark (1996)
J. Biol. Chem. 271, 12708-12715
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Cell surface changes associated with cellular immune reactions in Drosophila.
A. Nappi and M Silvers (1984)
Science 225, 1166-1168
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