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Science 1 April 1983:
Vol. 220. no. 4592, pp. 69 - 70
DOI: 10.1126/science.6828880
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Articles

Science, Vol 220, Issue 4592, 69-70
Copyright © 1983 by American Association for the Advancement of Science

articles

Fragile sites in chromosomes: possible model for the study of spontaneous chromosome breakage

PB Jacky, B Beek, and GR Sutherland

The tissue culture condition that is required for the type of chromosome breakage seen at most fragile sites, namely, the absence of folic acid and thymidine in the medium, greatly enhanced micronucleus formation in proliferating lymphocyte cultures from normal individuals. This suggests that chromosome breakage at fragile sites and the apparently spontaneous damage that gives rise to micronuclei are controlled by the same mechanism.


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