Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 25 March 1983:
Vol. 219. no. 4591, pp. 1453 - 1455
DOI: 10.1126/science.6298938
Prev | Table of Contents

Articles

Science, Vol 219, Issue 4591, 1453-1455
Copyright © 1983 by American Association for the Advancement of Science

articles

Tolerance develops to the disruptive effects of delta 9-tetrahydrocannabinol on primate menstrual cycle

CG Smith, RG Almirez, J Berenberg, and RH Asch

Long-term exposure of sexually mature female rhesus monkeys (Macaca mulata) to thrice weekly injections of delta 9-tetrahydrocannabinol resulted in a disruption of menstrual cycles that lasted for several months. This period was marked by an absence of ovulation and decreased basal concentrations of gonadotropin and sex steroids in the plasma. After this period, normal cycles and hormone concentrations were reestablished. These studies demonstrate that in rhesus monkeys subjected to long-term treatment with delta 9-tetrahydrocannabinol tolerance develops to the disruptive effects of the drug on the menstrual cycle.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance.
U. Pagotto, G. Marsicano, D. Cota, B. Lutz, and R. Pasquali (2006)
Endocr. Rev. 27, 73-100
   Abstract »    Full Text »    PDF »
Regulation of Gonadotropin-Releasing Hormone Secretion by Cannabinoids.
C. M. Gammon, G. M. Freeman Jr., W. Xie, S. L. Petersen, and W. C. Wetsel (2005)
Endocrinology 146, 4491-4499
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)