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Science 25 March 1983:
Vol. 219. no. 4591, pp. 1451 - 1453
DOI: 10.1126/science.6828874
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Articles

Science, Vol 219, Issue 4591, 1451-1453
Copyright © 1983 by American Association for the Advancement of Science

articles

Midbrain microinfusions of prolactin increase the estrogen-dependent behavior, lordosis

RE Harlan, BD Shivers, and DW Pfaff

Microinfusions of rat prolactin into the dorsal midbrain of estrogen-treated, ovariectomized rats increased lordosis behavior. Midbrain microinfusions of antiserum to prolactin into rats displaying maximum lordosis had the opposite effect. The distribution of a prolactin-like substance in the brain was studied immunocytochemically. The results suggest that a hypothalamic neuronal system projecting to the midbrain contains a prolactin-like substance that plays a role in facilitating this behavior and therefore may mediate some of the effects of estrogen on the brain. These data, together with others from studies of the prolactin gene and its regulation, indicate that it may be possible to analyze a sequence of molecular events in the brain that facilitate a behavioral response.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Identification of a Novel First Exon of Prolactin Receptor Gene Expressed in the Rat Brain.
M. Tanaka, Y. Hayashida, T. Iguchi, N. Nakao, M. Suzuki, N. Nakai, and K. Nakashima (2002)
Endocrinology 143, 2080-2084
   Abstract »    Full Text »    PDF »
Prolactin: Structure, Function, and Regulation of Secretion.
M. E. Freeman, B. Kanyicska, A. Lerant, and G. Nagy (2000)
Physiol Rev 80, 1523-1631
   Abstract »    Full Text »    PDF »
Central Neuronal Circuit Innervating the Lordosis-Producing Muscles Defined by Transneuronal Transport of Pseudorabies Virus.
D. Daniels, R. R. Miselis, and L. M. Flanagan-Cato (1999)
J. Neurosci. 19, 2823-2833
   Abstract »    Full Text »    PDF »
Evolutionary Change in the Endocrinology of Behavioral Receptivity: Divergent Roles for Progesterone and Prolactin within the Genus Phodopus.
H.J. McMillan and K.E. Wynne-Edwards (1998)
Biol Reprod 59, 30-38
   Abstract »    Full Text »
Prolactin (PRL) and Its Receptor: Actions, Signal Transduction Pathways and Phenotypes Observed in PRL Receptor Knockout Mice.
C. Bole-Feysot, V. Goffin, M. Edery, N. Binart, and P. A. Kelly (1998)
Endocr. Rev. 19, 225-268
   Abstract »    Full Text »
Prolactin stimulation of maternal behavior in female rats.
R. Bridges, R DiBiase, D. Loundes, and P. Doherty (1985)
Science 227, 782-784
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)