Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 18 March 1983:
Vol. 219. no. 4590, pp. 1349 - 1351
DOI: 10.1126/science.6828866
Prev | Table of Contents | Next

Articles

Science, Vol 219, Issue 4590, 1349-1351
Copyright © 1983 by American Association for the Advancement of Science

articles

Local differences in the amount of early cell death in neocortex predict adult local specializations

BL Finlay and M Slattery

The amount of early cell loss in five neocortical areas was inversely related to adult numbers of neurons in those areas. Differential cell death predicted particularly the thickness of the upper cortical laminae; it was not related to neuron numbers in the lower laminae. Cell loss thus determines some features of local neocortical differentiation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Postnatal Generation of Neurons in the Ventrobasal Nucleus of the Rat Thalamus.
S. M. Mooney and M. W. Miller (2007)
J. Neurosci. 27, 5023-5032
   Abstract »    Full Text »    PDF »
Developmental Cell Death Is Enhanced in the Cerebral Cortex of Mice Lacking the Brain Vesicular Monoamine Transporter.
L. Stankovski, C. Alvarez, T. Ouimet, T. Vitalis, K. H. El-Hachimi, D. Price, E. Deneris, P. Gaspar, and O. Cases (2007)
J. Neurosci. 27, 1315-1324
   Abstract »    Full Text »    PDF »
Our unborn children at risk?.
V. S. Caviness and P. E. Grant (2006)
PNAS 103, 12661-12662
   Full Text »    PDF »
Sequence of Neuron Origin and Neocortical Laminar Fate: Relation to Cell Cycle of Origin in the Developing Murine Cerebral Wall.
T. Takahashi, T. Goto, S. Miyama, R. S. Nowakowski, and V. S. Caviness Jr (1999)
J. Neurosci. 19, 10357-10371
   Abstract »    Full Text »    PDF »
Overlapping and Divergent Actions of Estrogen and the Neurotrophins on Cell Fate and p53-Dependent Signal Transduction in Conditionally Immortalized Cerebral Cortical Neuroblasts.
S. B. Wade, P. Oommen, W. C. Conner, D. J. Earnest, and R. C. Miranda (1999)
J. Neurosci. 19, 6994-7006
   Abstract »    Full Text »    PDF »
Multiple Roles of Bone Morphogenetic Protein Signaling in the Regulation of Cortical Cell Number and Phenotype.
P. C. Mabie, M. F. Mehler, and J. A. Kessler (1999)
J. Neurosci. 19, 7077-7088
   Abstract »    Full Text »    PDF »
Review : Cell Cycle as Operational Unit of Neocortical Neuronogenesis.
T. Takahashi, R.S. Nowakowski, and V.S. Caviness Jr (1999)
Neuroscientist 5, 155-163
   Abstract »    PDF »
Neurogenesis and Commitment of Corticospinal Neurons in reeler.
F. Polleux, C. Dehay, and H. Kennedy (1998)
J. Neurosci. 18, 9910-9923
   Abstract »    Full Text »    PDF »
Regulation of Neuroblast Cell-Cycle Kinetics Plays a Crucial Role in the Generation of Unique Features of Neocortical Areas.
F. Polleux, C. Dehay, B. Moraillon, and H. Kennedy (1997)
J. Neurosci. 17, 7763-7783
   Abstract »    Full Text »    PDF »
Apoptosis and Its Relation to the Cell Cycle in the Developing Cerebral Cortex.
D. Thomaidou, M. C. Mione, J. F. R. Cavanagh, and J. G. Parnavelas (1997)
J. Neurosci. 17, 1075-1085
   Abstract »    Full Text »    PDF »
The Leaving or Q Fraction of the Murine Cerebral Proliferative Epithelium: A General Model of Neocortical Neuronogenesis.
T. Takahashi, R. S. Nowakowski, and V. S. Caviness Jr. (1996)
J. Neurosci. 16, 6183-6196
   Abstract »    Full Text »    PDF »
Interkinetic and Migratory Behavior of a Cohort of Neocortical Neurons Arising in the Early Embryonic Murine Cerebral Wall.
T. Takahashi, R. S. Nowakowski, and V. S. Caviness Jr. (1996)
J. Neurosci. 16, 5762-5776
   Abstract »    Full Text »    PDF »
Cerebral Structural Abnormalities in Obsessive-compulsive Disorder: A Quantitative Morphometric Magnetic Resonance Imaging Study.
M. A. Jenike, H. C. Breiter, L. Baer, D. N. Kennedy, C. R. Savage, M. J. Olivares, R. L. O'Sullivan, D. M. Shera, S. L. Rauch, N. Keuthen, et al. (1996)
Arch Gen Psychiatry 53, 625-632
   Abstract »    PDF »
Influences of the Thalamus on the Survival of Subplate and Cortical Plate Cells in Cultured Embryonic Mouse Brain.
D. J. Price and R. B. Lotto (1996)
J. Neurosci. 16, 3247-3255
   Abstract »    Full Text »    PDF »
Maldistribution of Interstitial Neurons in Prefrontal White Matter of the Brains of Schizophrenic Patients.
S. Akbarian, J. J. Kim, S. G. Pothin, W. P. Hetrick, W. E. Bunney Jr, and E. G. Jones (1996)
Arch Gen Psychiatry 53, 425-436
   Abstract »    PDF »
Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex.
A. Blaschke, K Staley, and J Chun (1996)
Development 122, 1165-1174
   Abstract »    PDF »
Specification of cerebral cortical areas.
P Rakic (1988)
Science 241, 170-176
   Abstract »    PDF »
Androgens prevent normally occurring cell death in a sexually dimorphic spinal nucleus.
E. Nordeen, K. Nordeen, D. Sengelaub, and A. Arnold (1985)
Science 229, 671-673
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)