Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 18 March 1983:
Vol. 219. no. 4590, pp. 1341 - 1343
DOI: 10.1126/science.6828862
Prev | Table of Contents | Next

Articles

Science, Vol 219, Issue 4590, 1341-1343
Copyright © 1983 by American Association for the Advancement of Science

articles

Methoxyindoles and photoreceptor metabolism: activation of rod shedding

JC Besharse and DA Dunis

Using an in vitro eye-cup preparation, we have evaluated a potential relationship between methoxyindole metabolism and photoreceptor disk shedding. Melatonin, 6-chloromelatonin, and 5-methoxytryptophol all activate rod disk shedding in culture. The effect is compound specific since serotonin and N-acetylserotonin are without effect, and it is similar to shedding in vivo because it is evoked by light and is quantitatively comparable to a normal intact animal response. The results suggest the involvement of 5-methoxyindoles in the control of rhythmic photoreceptor metabolism.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Circadian Regulation of Retinoschisin in the Chick Retina.
M. L. Ko, Y. Liu, L. Shi, D. Trump, and G. Y.-P. Ko (2008)
Invest. Ophthalmol. Vis. Sci. 49, 1615-1621
   Abstract »    Full Text »    PDF »
Tyrosine Phosphorylation of cGMP-Gated Ion Channels Is under Circadian Control in Chick Retina Photoreceptors.
K.-S. Chae, G. Y.-P. Ko, and S. E. Dryer (2007)
Invest. Ophthalmol. Vis. Sci. 48, 901-906
   Abstract »    Full Text »    PDF »
Melatonin Receptors in Chick Ocular Tissues: Implications for a Role of Melatonin in Ocular Growth Regulation.
J. A. S. Rada and A. F. Wiechmann (2006)
Invest. Ophthalmol. Vis. Sci. 47, 25-33
   Abstract »    Full Text »    PDF »
Stimulation of Melatonin Receptors Decreases Calcium Levels in Xenopus Tectal Cells by Activating GABAC Receptors.
C. Prada, S. B. Udin, A. F. Wiechmann, and I. V. Zhdanova (2005)
J Neurophysiol 94, 968-978
   Abstract »    Full Text »    PDF »
Retinal Ganglion Cells Are Autonomous Circadian Oscillators Synthesizing N-Acetylserotonin during the Day.
E. Garbarino-Pico, A. R. Carpentieri, M. A. Contin, M. I. K. Sarmiento, M. A. Brocco, P. Panzetta, R. E. Rosenstein, B. L. Caputto, and M. E. Guido (2004)
J. Biol. Chem. 279, 51172-51181
   Abstract »    Full Text »    PDF »
Direct Modulation of Rod Photoreceptor Responsiveness through a Mel1c Melatonin Receptor in Transgenic Xenopus laevis Retina.
A. F. Wiechmann, M. J. Vrieze, R. Dighe, and Y. Hu (2003)
Invest. Ophthalmol. Vis. Sci. 44, 4522-4531
   Abstract »    Full Text »    PDF »
Correlating Retinal Function with Melatonin Secretion in Subjects with an Early or Late Circadian Phase.
M. Rufiange, M. Dumont, and P. Lachapelle (2002)
Invest. Ophthalmol. Vis. Sci. 43, 2491-2499
   Abstract »    Full Text »    PDF »
Retinal cAMP Levels during the Progression of Retinal Degeneration in Rhodopsin P23H and S334ter Transgenic Rats.
V. Traverso, R. A. Bush, P. A. Sieving, and D. Deretic (2002)
Invest. Ophthalmol. Vis. Sci. 43, 1655-1661
   Abstract »    Full Text »    PDF »
MT1 Melatonin Receptor in the Human Retina: Expression and Localization.
J. Scher, E. Wankiewicz, G. M. Brown, and H. Fujieda (2002)
Invest. Ophthalmol. Vis. Sci. 43, 889-897
   Abstract »    Full Text »    PDF »
Dopamine Decreases Melatonin Content in Golden Hamster Retina.
C. O. Jaliffa, F. F. Lacoste, D. W. Llomovatte, M. I. K. Sarmiento, and R. E. Rosenstein (2000)
J. Pharmacol. Exp. Ther. 293, 91-95
   Abstract »    Full Text »
Two Arylalkylamine N-Acetyltransferase Genes Mediate Melatonin Synthesis in Fish.
S. L. Coon, V. Begay, D. Deurloo, J. Falcon, and D. C. Klein (1999)
J. Biol. Chem. 274, 9076-9082
   Abstract »    Full Text »    PDF »
Cellular Mechanisms of Melatonin Action.
J. VANECEK (1998)
Physiol Rev 78, 687-721
   Abstract »    Full Text »    PDF »
The Visual Input Stage of the Mammalian Circadian Pacemaking System: I. Is There a Clock in the Mammalian Eye?.
C. E. Reme, A. Wirz-Justice, and M. Terman (1991)
J Biol Rhythms 6, 5-29
   Abstract »    PDF »
Melatonin Does Not Link the Eyes to the Rest of the Circadian System in Quail: A Neural Pathway Is Involved.
H. Underwood, R. K. Barrett, and T. Siopes (1990)
J Biol Rhythms 5, 349-361
   Abstract »    PDF »
Vertebrate Circadian and Photoperiodic Systems: Role of the Pineal Gland and Melatonin.
H. Underwood and B. D. Goldman (1987)
J Biol Rhythms 2, 279-315
   PDF »
Diurnal expression of transducin mRNA and translocation of transducin in rods of rat retina.
M. Brann and L. Cohen (1987)
Science 235, 585-587
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)