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Science 18 March 1983:
Vol. 219. no. 4590, pp. 1339 - 1341
DOI: 10.1126/science.6187067
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Articles

Science, Vol 219, Issue 4590, 1339-1341
Copyright © 1983 by American Association for the Advancement of Science

articles

Tunicamycin enhances the antiviral and anticellular activity of interferon

RK Maheshwari, T Sreevalsan, RH Silverman, J Hay, and RM Friedman

The inhibitory effects of interferon on virus multiplication and cell growth are significantly enhanced by treatment with tunicamycin. Potentiation of antiviral activity was found only with enveloped viruses and not with nonbudding viruses. Changes in the plasma membrane of treated cells may account for this effect, since enveloped viruses bud from the cell surface as a terminal step.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)