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Science 18 March 1983:
Vol. 219. no. 4590, pp. 1331 - 1333
DOI: 10.1126/science.6298936
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Articles

Science, Vol 219, Issue 4590, 1331-1333
Copyright © 1983 by American Association for the Advancement of Science

articles

Demonstration of a saturable binding site for thyrotropin in Yersinia enterocolitica

M Weiss, SH Ingbar, S Winblad, and DL Kasper

Several lines of evidence suggest that there might be immunologic cross-reactivity between the thyroid plasma membrane in humans and antigenic determinants in the enteric pathogen Yersinia enterocolitica. Studies were therefore performed to determine whether Y. enterocolitica, like the thyroid membrane, contains a thyrotropin binding site. A saturable binding site for bovine thyrotropin was indeed demonstrable, particularly in preparations of the organism that have been treated with ethylenediaminetetraacetate and lysozyme. Hormonal specificity of the binding site, as judged from the inhibition of binding of 125I-labeled bovine thyrotropin, was similar to that of the thyrotropin receptor in human thyroid tissue.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Helicobacter pylori Infection and Autoimmune Thyroid Disease in Young Patients: The Disadvantage of Carrying the Human Leukocyte Antigen-DRB1*0301 Allele.
D. Larizza, V. Calcaterra, M. Martinetti, R. Negrini, A. De Silvestri, M. Cisternino, A. M. Iannone, and E. Solcia (2006)
J. Clin. Endocrinol. Metab. 91, 176-179
   Abstract »    Full Text »    PDF »
Affinity-Enrichment of Thyrotropin Receptor Autoantibodies from Graves' Patients and Normal Individuals Provides Insight into Their Properties and Possible Origin from Natural Antibodies.
F. Latrofa, G. D. Chazenbalk, P. Pichurin, C.-R. Chen, S. M. McLachlan, and B. Rapoport (2004)
J. Clin. Endocrinol. Metab. 89, 4734-4745
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Current Perspective on the Pathogenesis of Graves' Disease and Ophthalmopathy.
B. S. Prabhakar, R. S. Bahn, and T. J. Smith (2003)
Endocr. Rev. 24, 802-835
   Abstract »    Full Text »    PDF »
The Mammalian Neuroendocrine Hormone Norepinephrine Supplies Iron for Bacterial Growth in the Presence of Transferrin or Lactoferrin.
P. P. E. Freestone, M. Lyte, C. P. Neal, A. F. Maggs, R. D. Haigh, and P. H. Williams (2000)
J. Bacteriol. 182, 6091-6098
   Abstract »    Full Text »
The Thyrotropin (TSH)-Releasing Hormone Receptor: Interaction with TSH and Autoantibodies.
B. Rapoport, G. D. Chazenbalk, J. C. Jaume, and S. M. McLachlan (1998)
Endocr. Rev. 19, 673-716
   Abstract »    Full Text »
Tobacco and Graves' Disease: Smoking Gun or Smoke and Mirrors?.
D. S. Cooper (1993)
JAMA 269, 518-519
   Abstract »    PDF »
Conjugal Graves Disease.
S. A. Ebner, M.-C. Badonnel, L. K. Altman, and L. E. Braverman (1992)
Ann Intern Med 116, 479-481
   Abstract »    PDF »


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