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Science 18 March 1983:
Vol. 219. no. 4590, pp. 1327 - 1329
DOI: 10.1126/science.6828859
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Articles

Science, Vol 219, Issue 4590, 1327-1329
Copyright © 1983 by American Association for the Advancement of Science

articles

Role of surface-active phospholipids in gastric cytoprotection

LM Lichtenberger, LA Graziani, EJ Dial, BD Butler, and BA Hills

Intragastric administration of a liposomal surfactant suspension markedly reduced acid-induced gastric ulcerogenesis and bleeding in rats. The concentration of surface-active molecules intrinsically present in the gastric mucosa was increased two to six times by administration of 16,16-dimethyl prostaglandin E2. Thus, local accumulation of surface-active phospholipids may be an integral component of the cytoprotective mechanism activated by prostaglandin treatment.


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