Related Content
Search Google Scholar for:
|
|
Science 11 March 1983:
Vol. 219. no. 4589, pp. 1230 - 1232
DOI: 10.1126/science.6131536
|
|
Articles
Science, Vol 219, Issue 4589, 1230-1232
Copyright © 1983 by American Association for the Advancement of Science
An excitatory amino acid antagonist blocks cone input to sign-conserving second-order retinal neurons
MM Slaughter
and
RF Miller
cis-2,3-Piperidinedicarboxylic acid (PDA), an excitatory amino acid antagonist, reversibly blocked cone input to OFF bipolars and horizontal cells, whereas ON bipolars were relatively unaffected. Kainic acid effects were also blocked, indicating a postsynaptic mechanism of action. The use of PDA helps to characterize one of two classes of excitatory amino acid synaptic receptors that mediate cone influence in the outer retina.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Cell Communication Mechanisms in the Vertebrate Retina The Proctor Lecture.
- R. F. Miller (2008)
Invest. Ophthalmol. Vis. Sci.
49, 5184-5198
| Abstract »
| Full Text »
| PDF »
- Amacrine-to-Amacrine Cell Inhibition in the Rabbit Retina.
- H.-A. Hsueh, A. Molnar, and F. S. Werblin (2008)
J Neurophysiol
100, 2077-2088
| Abstract »
| Full Text »
| PDF »
- Influence of a Quantitative Trait Locus on Mouse Chromosome 19 to the Light-Adapted Electroretinogram.
- A. L. Reynolds, M. Danciger, G. J. Farrar, P. Humphries, and P. F. Kenna (2008)
Invest. Ophthalmol. Vis. Sci.
49, 4058-4063
| Abstract »
| Full Text »
| PDF »
- Effects of Spectral Characteristics of Ganzfeld Stimuli on the Photopic Negative Response (PhNR) of the ERG.
- N. V. Rangaswamy, S. Shirato, M. Kaneko, B. I. Digby, J. G. Robson, and L. J. Frishman (2007)
Invest. Ophthalmol. Vis. Sci.
48, 4818-4828
| Abstract »
| Full Text »
| PDF »
- Presynaptic inhibition differentially shapes transmission in distinct circuits in the mouse retina.
- E. D. Eggers, M. A. McCall, and P. D. Lukasiewicz (2007)
J. Physiol.
582, 569-582
| Abstract »
| Full Text »
| PDF »
- Parallel Processing in Retinal Ganglion Cells: How Integration of Space-Time Patterns of Excitation and Inhibition Form the Spiking Output.
- B. Roska, A. Molnar, and F. S. Werblin (2006)
J Neurophysiol
95, 3810-3822
| Abstract »
| Full Text »
| PDF »
- Loss of Circadian Photoentrainment and Abnormal Retinal Electrophysiology in Math5 Mutant Mice.
- J. A. Brzezinski IV, N. L. Brown, A. Tanikawa, R. A. Bush, P. A. Sieving, M. H. Vitaterna, J. S. Takahashi, and T. Glaser (2005)
Invest. Ophthalmol. Vis. Sci.
46, 2540-2551
| Abstract »
| Full Text »
| PDF »
- Group III Metabotropic Glutamate Receptors and Exocytosed Protons Inhibit L-Type Calcium Currents in Cones But Not in Rods.
- N. Hosoi, I. Arai, and M. Tachibana (2005)
J. Neurosci.
25, 4062-4072
| Abstract »
| Full Text »
| PDF »
- Retinal Bipolar Cell Input Mechanisms in Giant Danio. I. Electroretinographic Analysis.
- K. Y. Wong, A. R. Adolph, and J. E. Dowling (2005)
J Neurophysiol
93, 84-93
| Abstract »
| Full Text »
| PDF »
- Paired-Flash Identification of Rod and Cone Dysfunction in the Diabetic Rat.
- J. A. Phipps, E. L. Fletcher, and A. J. Vingrys (2004)
Invest. Ophthalmol. Vis. Sci.
45, 4592-4600
| Abstract »
| Full Text »
| PDF »
- Photopic ERGs in Patients with Optic Neuropathies: Comparison with Primate ERGs after Pharmacologic Blockade of Inner Retina.
- N. V. Rangaswamy, L. J. Frishman, E. U. Dorotheo, J. S. Schiffman, H. M. Bahrani, and R. A. Tang (2004)
Invest. Ophthalmol. Vis. Sci.
45, 3827-3837
| Abstract »
| Full Text »
| PDF »
- Luminance Dependence of Neural Components that Underlies the Primate Photopic Electroretinogram.
- S. Ueno, M. Kondo, Y. Niwa, H. Terasaki, and Y. Miyake (2004)
Invest. Ophthalmol. Vis. Sci.
45, 1033-1040
| Abstract »
| Full Text »
| PDF »
- Post-Photoreceptoral Activity Dominates Primate Photopic 32-Hz ERG for Sine-, Square-, and Pulsed Stimuli.
- M. Kondo and P. A. Sieving (2002)
Invest. Ophthalmol. Vis. Sci.
43, 2500-2507
| Abstract »
| Full Text »
| PDF »
- Primate Photopic Sine-Wave Flicker ERG: Vector Modeling Analysis of Component Origins Using Glutamate Analogs.
- M. Kondo and P. A. Sieving (2001)
Invest. Ophthalmol. Vis. Sci.
42, 305-312
| Abstract »
| Full Text »
- Functional Architecture of Synapses in the Inner Retina: Segregation of Visual Signals by Stratification of Bipolar Cell Axon Terminals.
- S. M. Wu, F. Gao, and B. R. Maple (2000)
J. Neurosci.
20, 4462-4470
| Abstract »
| Full Text »
| PDF »
- Light-Evoked Excitatory Synaptic Currents of X-Type Retinal Ganglion Cells.
- E. D. Cohen (2000)
J Neurophysiol
83, 3217-3229
| Abstract »
| Full Text »
| PDF »
- I4AA-Sensitive Chloride Current Contributes to the Center Light Responses of Bipolar Cells in the Tiger Salamander Retina.
- F. Gao, B. R. Maple, and S. M. Wu (2000)
J Neurophysiol
83, 3473-3482
| Abstract »
| Full Text »
| PDF »
- Response characteristics and receptive field widths of on-bipolar cells in the mouse retina.
- A. Berntson and W R. Taylor (2000)
J. Physiol.
524, 879-889
| Abstract »
| Full Text »
| PDF »
- Glutamate Uptake Limits Synaptic Excitation of Retinal Ganglion Cells.
- M. H. Higgs and P. D. Lukasiewicz (1999)
J. Neurosci.
19, 3691-3700
| Abstract »
| Full Text »
| PDF »
- Interactions of Inhibition and Excitation in the Light-Evoked Currents of X Type Retinal Ganglion Cells.
- E. D. Cohen (1998)
J Neurophysiol
80, 2975-2990
| Abstract »
| Full Text »
| PDF »
- Circadian Rhythms of Rod-Cone Dominance in the Japanese Quail Retina.
- M. K. Manglapus, H. Uchiyama, N. F. Buelow, and R. B. Barlow (1998)
J. Neurosci.
18, 4775-4784
| Abstract »
| Full Text »
| PDF »
- Glycinergic synaptic inputs to bipolar cells in the salamander retina.
- B. R Maple and S. M Wu (1998)
J. Physiol.
506, 731-744
| Abstract »
| Full Text »
| PDF »
- AMPA-Preferring Receptors Mediate Excitatory Synaptic Inputs to Retinal Ganglion Cells.
- P. D. Lukasiewicz, J. A. Wilson, and J. E. Lawrence (1997)
J Neurophysiol
77, 57-64
| Abstract »
| Full Text »
| PDF »
|
|
