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Science 11 March 1983:
Vol. 219. no. 4589, pp. 1223 - 1225
DOI: 10.1126/science.6828852
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Articles

Science, Vol 219, Issue 4589, 1223-1225
Copyright © 1983 by American Association for the Advancement of Science

articles

In vivo phosphorus-31 nuclear magnetic resonance reveals lowered ATP during heat shock of Tetrahymena

RC Findly, RJ Gillies, and RG Shulman

Cells synthesize a characteristic set of proteins--heat shock proteins--in response to a rapid temperature jump or certain other stress treatments. The technique of phosphorus-31 nuclear magnetic resonance spectroscopy was used to examine in vivo the effects of temperature jump on two species of Tetrahymena that initiate the heat shock response at different temperatures. An immediate 50 percent decrease in cellular adenosine triphosphate was observed when either species was jumped to a temperature that strongly induces synthesis of heat shock proteins. This new adenosine triphosphate concentration was maintained at the heat shock temperature.


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