Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 4 March 1983:
Vol. 219. no. 4588, pp. 1089 - 1091
DOI: 10.1126/science.6823571
Prev | Table of Contents | Next

Articles

Science, Vol 219, Issue 4588, 1089-1091
Copyright © 1983 by American Association for the Advancement of Science

articles

Free-running activity rhythms in the rat: entrainment by melatonin

J Redman, S Armstrong, and KT Ng

The pineal gland hormone melatonin may play a role in synchronization of rat circadian rhythms. Free-running activity rhythms of the rat were entrained by a daily melatonin injection, with entrainment occurring when the onset of activity coincided with the time of daily injections. When injections were stopped, activity rhythms became free-running again. Thus in pharmacological experiments, the time of day of melatonin administration is crucial.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Molecular Cloning and Pharmacological Characterization of Monkey MT1 and MT2 Melatonin Receptors Showing High Affinity for the Agonist Ramelteon.
K. Nishiyama, Y. Shintani, K. Hirai, and S.-i. Yoshikubo (2009)
J. Pharmacol. Exp. Ther. 330, 855-863
   Abstract »    Full Text »    PDF »
Agomelatine, an innovative pharmacological response to unmet needs..
Y Le Strat and P Gorwood (2008)
J Psychopharmacol 22, 4-8
   Abstract »    PDF »
A three pulse phase response curve to three milligrams of melatonin in humans.
H. J. Burgess, V. L. Revell, and C. I. Eastman (2008)
J. Physiol. 586, 639-647
   Abstract »    Full Text »    PDF »
Melatonin and Human Chronobiology.
A. J. Lewy (2007)
Cold Spring Harb Symp Quant Biol 72, 623-636
   Abstract »    PDF »
Multiple Effects of Melatonin on Rhythmic Clock Gene Expression in the Mammalian Pars Tuberalis.
J. D. Johnston, B. B. Tournier, H. Andersson, M. Masson-Pevet, G. A. Lincoln, and D. G. Hazlerigg (2006)
Endocrinology 147, 959-965
   Abstract »    Full Text »    PDF »
The role of circadian rhythmicity in reproduction.
D. J. Kennaway (2005)
Hum. Reprod. Update 11, 91-101
   Abstract »    Full Text »    PDF »
Eventual Entrainment of the Human Circadian Pacemaker by Melatonin is Independent of the Circadian Phase of Treatment Initiation: Clinical Implications.
A. J. Lewy, J. S. Emens, R. A. Bernert, and B. J. Lefler (2004)
J Biol Rhythms 19, 68-75
   Abstract »    PDF »
Melatonin in Patients with Reduced REM Sleep Duration: Two Randomized Controlled Trials.
D. Kunz, R. Mahlberg, C. Muller, A. Tilmann, and F. Bes (2004)
J. Clin. Endocrinol. Metab. 89, 128-134
   Abstract »    Full Text »    PDF »
The Effects of Low-Dose 0.5-mg Melatonin on the Free-Running Circadian Rhythms of Blind Subjects.
L. M. Hack, S. W. Lockley, J. Arendt, and D. J. Skene (2003)
J Biol Rhythms 18, 420-429
   Abstract »    PDF »
Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters.
V. Simonneaux and C. Ribelayga (2003)
Pharmacol. Rev. 55, 325-395
   Abstract »    Full Text »    PDF »
Melatonin phase shifts human circadian rhythms in a placebo-controlled simulated night-work study.
K. M. Sharkey and C. I. Eastman (2002)
Am J Physiol Regulatory Integrative Comp Physiol 282, R454-R463
   Abstract »    Full Text »    PDF »
Melatonin or a melatonin agonist corrects age-related changes in circadian response to environmental stimulus.
O. Van Reeth, L. Weibel, E. Olivares, S. Maccari, E. Mocaer, and F. W. Turek (2001)
Am J Physiol Regulatory Integrative Comp Physiol 280, R1582-R1591
   Abstract »    Full Text »    PDF »
Diminished Melatonin Secretion in the Elderly Caused by Insufficient Environmental Illumination.
K. Mishima, M. Okawa, T. Shimizu, and Y. Hishikawa (2001)
J. Clin. Endocrinol. Metab. 86, 129-134
   Abstract »    Full Text »
Melatonin protects against 6-OHDA-induced neurotoxicity in rats: a role for mitochondrial complex I activity.
F. DABBENI-SALA, S. DI SANTO, D. FRANCESCHINI, S. D. SKAPER, and P. GIUSTI (2001)
FASEB J 15, 164-170
   Abstract »    Full Text »    PDF »
Activation of MT2 melatonin receptors in rat suprachiasmatic nucleus phase advances the circadian clock.
A. E. Hunt, W. M. Al-Ghoul, M. U. Gillette, and M. L. Dubocovich (2001)
Am J Physiol Cell Physiol 280, C110-C118
   Abstract »    Full Text »    PDF »
Melatonin Suppression by Light in Euthymic Bipolar and Unipolar Patients.
J. I. Nurnberger Jr, S. Adkins, D. K. Lahiri, A. Mayeda, K. Hu, A. Lewy, A. Miller, E. S. Bowman, M. J. Miller, N. L. Rau, et al. (2000)
Arch Gen Psychiatry 57, 572-579
   Abstract »    Full Text »    PDF »
Influence of the Mode of Daily Melatonin Administration on Entrainment of Rat Circadian Rhythms.
H. A. Slotten, B. Pitrosky, and P. Pevet (1999)
J Biol Rhythms 14, 347-353
   Abstract »    PDF »
Organization of rat circadian rhythms during daily infusion of melatonin or S20098, a melatonin agonist.
B. Pitrosky, R. Kirsch, A. Malan, E. Mocaer, and P. Pevet (1999)
Am J Physiol Regulatory Integrative Comp Physiol 277, R812-R828
   Abstract »    Full Text »    PDF »
The Effect of Multiple Pulses of Light on the Circadian Phase Response of the Rat.
M. A. Stokes, S. Kent, and S. M. Armstrong (1999)
J Biol Rhythms 14, 172-184
   Abstract »    PDF »
Pineal-Independent Regulation of Photo-Nonresponsiveness in the Siberian Hamster (Phodopus sungorus).
B. J. Prendergast and D. A. Freeman (1999)
J Biol Rhythms 14, 62-71
   Abstract »    PDF »
Thermoregulatory and soporific effects of very low dose melatonin injection.
C. J. van den Heuvel, D. J. Kennaway, and D. Dawson (1999)
Am J Physiol Endocrinol Metab 276, E249-E254
   Abstract »    Full Text »    PDF »
CREB in the Mouse SCN: A Molecular Interface Coding the Phase-Adjusting Stimuli Light, Glutamate, PACAP, and Melatonin for Clockwork Access.
C. von Gall, G. E. Duffield, M. H. Hastings, M. D. A. Kopp, F. Dehghani, H.-W. Korf, and J. H. Stehle (1998)
J. Neurosci. 18, 10389-10397
   Abstract »    Full Text »    PDF »
Cellular Mechanisms of Melatonin Action.
J. VANECEK (1998)
Physiol Rev 78, 687-721
   Abstract »    Full Text »    PDF »
Entrainment of Rat Circadian Rhythms by the Melatonin Agonist S-20098 Requires Intact Suprachiasmatic Nuclei But Not the Pineal.
J. R. Redman and A. J. P. Francis (1998)
J Biol Rhythms 13, 39-51
   Abstract »    PDF »
Alterations of Estrous Activity in the Ewe by Circadian-Based Manipulation of the Endogenous Pacemaker.
M. V. Guerin and C. D. Matthews (1998)
J Biol Rhythms 13, 60-69
   Abstract »    PDF »
Time and Time Again: The Phylogeny of Melatonin as a Transducer of Biological Time.
V. M. Cassone and A. K. Natesan (1997)
J Biol Rhythms 12, 489-497
   Abstract »    PDF »
Circadian Entrainment and Phase Shifting in Mammals with Melatonin.
J. R. Redman (1997)
J Biol Rhythms 12, 581-587
   Abstract »    PDF »
Exogenous Melatonin's Phase-Shifting Effects on the Endogenous Melatonin Profile in Sighted Humans: A Brief Review and Critique of the Literature.
A. J. Lewy and R. L. Sack (1997)
J Biol Rhythms 12, 588-594
   Abstract »    PDF »
Melatonin as a Chronobiotic: Treatment of Circadian Desynchrony in Night Workers and the Blind.
R. L. Sack and A. J. Lewy (1997)
J Biol Rhythms 12, 595-603
   Abstract »    PDF »
Effects of Daily Melatonin Administration on Circadian Activity Rhythms in the Diurnal Indian Palm Squirrel (Funambulus pennanti.
S.M.W. Rajaratnam and J.R. Redman (1997)
J Biol Rhythms 12, 339-347
   Abstract »    PDF »
Melatonin and Light Induce Phase Shifts of Circadian Activity Rhythms in the C3H/HeN Mouse.
S. Benloucif and M. L. Dubocovich (1996)
J Biol Rhythms 11, 113-125
   Abstract »    PDF »
Is a Critical Interval of the Circadian Pacemaker at Dusk Responsive to Light and Melatonin Responsible for the Timing of Estrus in the Romney Marsh Ewe?.
C. D. Matthews, M. V. Guerin, and A. J. Napier (1995)
J Biol Rhythms 10, 308-318
   Abstract »    PDF »
The Pineal Gland: Photoreception and Coupling of Behavioral, Metabolic, and Cardiovascular Circadian Outputs.
W. S. Warren and V. M. Cassone (1995)
J Biol Rhythms 10, 64-79
   Abstract »    PDF »
Influence of Acute Melatonin Treatment and Light on the Circadian Melatonin Rhythm in the Djungarian Hamster.
S. M. Yellon and S. Hilliker (1994)
J Biol Rhythms 9, 71-81
   Abstract »    PDF »
Age, but Not Pineal Status, Modulates Circadian Periodicity of Golden Hamsters.
L. P. Morin (1993)
J Biol Rhythms 8, 189-197
   Abstract »    PDF »
Pinealectomized Rats Entrain and Phase-Shift to Melatonin Injections in a Dose-Dependent Manner.
W. S. Warren, D. B. Hodges, and V. M. Cassone (1993)
J Biol Rhythms 8, 233-245
   Abstract »    PDF »
The Pineal Gland Influences Rat Circadian Activity Rhythms in Constant Light.
V. M. Cassone (1992)
J Biol Rhythms 7, 27-40
   Abstract »    PDF »
Melatonin Administration to Blind People: Phase Advances and Entrainment.
R. L. Sack, A. J. Lewy, M. L. Blood, J. Stevenson, and L. D. Keith (1991)
J Biol Rhythms 6, 249-261
   Abstract »    PDF »
Bright light induction of strong (type 0) resetting of the human circadian pacemaker.
C. Czeisler, R. Kronauer, J. Allan, J. Duffy, M. Jewett, E. Brown, and J. Ronda (1989)
Science 244, 1328-1333
   Abstract »    PDF »
Putative melatonin receptors in a human biological clock.
S. Reppert, D. Weaver, S. Rivkees, and E. Stopa (1988)
Science 242, 78-81
   Abstract »    PDF »
Dose-Dependent Entrainment of Rat Circadian Rhythms by Daily Injection of Melatonin.
V. M. Cassone, M. J. Chesworth, and S. M. Armstrong (1986)
J Biol Rhythms 1, 219-229
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)