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Science 4 March 1983:
Vol. 219. no. 4588, pp. 1085 - 1087
DOI: 10.1126/science.6600521
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Articles

Science, Vol 219, Issue 4588, 1085-1087
Copyright © 1983 by American Association for the Advancement of Science

articles

Discrete visual defects in pearl mutant mice

GW Balkema, NJ Mangini, and LH Pinto

The mutant mouse pearl, characterized by its hypopigmentation, has a specific functional defect in a sensory system--the retina. The intact pearl mouse has reduced sensitivity in the dark-adapted condition. Normal sensitivity is restored by isolation and superfusion of the retina with bicarbonate-buffered Ringer solution, suggesting that the retinal expression of the pearl mutation depends on a diffusible substance. The pearl phenotype is described as a possible model for human congenital stationary night blindness.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Elevated Free Calcium Levels in the Subretinal Space Elevate the Absolute Dark-Adapted Threshold in Hypopigmented Mice.
C. R. Lavallee, J. R. Chalifoux, A. J. Moosally, and G. W. Balkema (2003)
J Neurophysiol 90, 3654-3662
   Abstract »    Full Text »    PDF »
Sequences Associated With Human Iris Pigmentation.
T. Frudakis, M. Thomas, Z. Gaskin, K. Venkateswarlu, K. S. Chandra, S. Ginjupalli, S. Gunturi, S. Natrajan, V. K. Ponnuswamy, and K. N. Ponnuswamy (2003)
Genetics 165, 2071-2083
   Abstract »    Full Text »    PDF »
Abnormal Expression and Subcellular Distribution of Subunit Proteins of the AP-3 Adaptor Complex Lead to Platelet Storage Pool Deficiency in the Pearl Mouse.
L. Zhen, S. Jiang, L. Feng, N. A. Bright, A. A. Peden, A. B. Seymour, E. K. Novak, R. Elliott, M. B. Gorin, M. S. Robinson, et al. (1999)
Blood 94, 146-155
   Abstract »    Full Text »    PDF »
An integrated genetic map of the pearl locus of mouse chromosome 13..
A B Seymour, B L Yanak, E P O'Brien, M E Rusiniak, E K Novak, L H Pinto, R T Swank, and M B Gorin (1996)
Genome Res. 6, 538-544
   Abstract »    PDF »


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