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Science 4 March 1983:
Vol. 219. no. 4588, pp. 1081 - 1083
DOI: 10.1126/science.6823569
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Articles

Science, Vol 219, Issue 4588, 1081-1083
Copyright © 1983 by American Association for the Advancement of Science

articles

Human c-Ki-ras2 proto-oncogene on chromosome 12

AY Sakaguchi, SL Naylor, TB Shows, JJ Toole, M McCoy, and RA Weinberg

A human colonic adenocarcinoma transforming gene, recently identified as a cellular homolog of the Kirsten sarcoma gene (v-ras), was used to assign the human cellular Kirsten ras2 gene to chromosome 12 by the Southern hybridization method. A single 640 base-pair Eco RI--Hind III fragment of the transforming gene, isolated by DNA transfection and molecular cloning, can detect a single Eco RI fragment (2.9 kilobase pairs) of DNA from phenotypically normal cells. The data suggest a constant chromosomal location of c-Ki-ras2.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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