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Science 25 February 1983:
Vol. 219. no. 4587, pp. 983 - 985
DOI: 10.1126/science.6823562

Articles

Science, Vol 219, Issue 4587, 983-985
Copyright © 1983 by American Association for the Advancement of Science


articles

Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid

DR Senger, SJ Galli, AM Dvorak, CA Perruzzi, VS Harvey, and HF Dvorak

Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability. Similar activity is also secreted by these tumor cells and a variety of other tumor cell lines in vitro. The permeability-increasing activity purified from either the culture medium or ascites fluid of one tumor, the guinea pig line 10 hepatocarcinoma, is a 34,000- to 42,000-dalton protein distinct from other known permeability factors.


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Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality.
K. Yano, P. C. Liaw, J. M. Mullington, S.-C. Shih, H. Okada, N. Bodyak, P. M. Kang, L. Toltl, B. Belikoff, J. Buras, et al. (2006)
J. Exp. Med. 203, 1447-1458
   Abstract »    Full Text »    PDF »
Hepatocyte Growth Factor Induces Retinal Vascular Permeability via MAP-Kinase and PI-3 Kinase without Altering Retinal Hemodynamics..
A. C. Clermont, M. Cahill, H. Salti, S. L. Rook, C. Rask-Madsen, L. Goddard, J. S. Wong, D. Bursell, S. E. Bursell, and L. P. Aiello (2006)
Invest. Ophthalmol. Vis. Sci. 47, 2701-2708
   Abstract »    Full Text »    PDF »
Increased Vascular Endothelial Growth Factor and Receptors: Relationship to Angiogenesis in Asthma.
B. N. Feltis, D. Wignarajah, L. Zheng, C. Ward, D. Reid, R. Harding, and E. H. Walters (2006)
Am. J. Respir. Crit. Care Med. 173, 1201-1207
   Abstract »    Full Text »    PDF »
Antiangiogenic therapy: a universal chemosensitization strategy for cancer?.
R. S. Kerbel (2006)
Science 312, 1171-1175
   Abstract »    Full Text »    PDF »
Neovascularization in Human Atherosclerosis.
P. R. Moreno, K-R. Purushothaman, M. Sirol, A. P. Levy, and V. Fuster (2006)
Circulation 113, 2245-2252
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Growth Factors and the Epididymis.
J. L. Tomsig and T. T. Turner (2006)
J Androl 27, 348-357
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The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin.
Y. Huang, H. Shi, H. Zhou, X. Song, S. Yuan, and Y. Luo (2006)
Blood 107, 3564-3571
   Abstract »    Full Text »    PDF »
The anti-angiogenic VEGF isoform VEGF165b transiently increases hydraulic conductivity, probably through VEGF receptor 1 in vivo.
C. A. Glass, S. J. Harper, and D. O. Bates (2006)
J. Physiol. 572, 243-257
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Albendazole: a Potent Inhibitor of Vascular Endothelial Growth Factor and Malignant Ascites Formation in OVCAR-3 Tumor-Bearing Nude Mice..
M. Hossein Pourgholami, Z. Yan Cai, Y. Lu, L. Wang, and D. Lawson Morris (2006)
Clin. Cancer Res. 12, 1928-1935
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Targeting Angiogenesis With Integrative Cancer Therapies.
D. R. Yance Jr and S. M. Sagar (2006)
Integr Cancer Ther 5, 9-29
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Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds.
J. Pilch, D. M. Brown, M. Komatsu, T. A. H. Jarvinen, M. Yang, D. Peters, R. M. Hoffman, and E. Ruoslahti (2006)
PNAS 103, 2800-2804
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Review of the Effects of Anti-Angiogenic Compounds on the Epiphyseal Growth Plate.
A. P. Hall, F. R. Westwood, and P. F. Wadsworth (2006)
Toxicol Pathol 34, 131-147
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Effect of Inhibition of Vascular Endothelial Growth Factor Signaling on Distribution of Extravasated Antibodies in Tumors.
T. Nakahara, S. M. Norberg, D. R. Shalinsky, D. D. Hu-Lowe, and D. M. McDonald (2006)
Cancer Res. 66, 1434-1445
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Overcoming Physiologic Barriers to Cancer Treatment by Molecularly Targeting the Tumor Microenvironment.
R. Cairns, I. Papandreou, and N. Denko (2006)
Mol. Cancer Res. 4, 61-70
   Abstract »    Full Text »    PDF »



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