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Science 25 February 1983:
Vol. 219. no. 4587, pp. 977 - 979
DOI: 10.1126/science.6823560
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Articles

Science, Vol 219, Issue 4587, 977-979
Copyright © 1983 by American Association for the Advancement of Science

articles

Resistance to a malignant lymphoma in chickens is mapped to subregion of major histocompatibility (B) complex

WE Briles, RW Briles, RE Taffs, and HA Stone

A genetic recombinant within the major histocompatibility (B) complex of the chicken has revealed the chromosomal subregion effecting resistance to Marek's disease--a malignant lymphoma induced by a herpesvirus. The recombinant, BF21-G19, occurred spontaneously among the progeny of a male heterozygous for resistant BF21-G21 and susceptible BF19-G19 haplotypes. Exposure to Marek's disease of families segregating for the recombinant showed that this new F-G arrangement conferred a level of resistance equivalent to that of the resistant parental haplotype. Thus, a gene, or genes, within or closely linked to the B-F region of the B complex appears to be responsible for the observed resistance to Marek's disease.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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BG1 has a major role in MHC-linked resistance to malignant lymphoma in the chicken.
R. M. Goto, Y. Wang, R. L. Taylor Jr., P. S. Wakenell, K. Hosomichi, T. Shiina, C. S. Blackmore, W. E. Briles, and M. M. Miller (2009)
PNAS 106, 16740-16745
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Lifetime reproductive success is maximized with optimal major histocompatibility complex diversity.
M. Kalbe, C. Eizaguirre, I. Dankert, T. B.H Reusch, R. D Sommerfeld, K. M. Wegner, and M. Milinski (2009)
Proc R Soc B 276, 925-934
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Contribution of Mutation, Recombination, and Gene Conversion to Chicken Mhc-B Haplotype Diversity.
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Extended Gene Map Reveals Tripartite Motif, C-Type Lectin, and Ig Superfamily Type Genes within a Subregion of the Chicken MHC-B Affecting Infectious Disease.
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J. Immunol. 178, 7162-7172
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The Avian Major Histocompatibility Complex Influences Bacterial Skeletal Disease in Broiler Breeder Chickens.
K. S. Joiner, F. J. Hoerr, E. van Santen, and S. J. Ewald (2005)
Vet. Pathol. 42, 275-281
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