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Science 25 February 1983:
Vol. 219. no. 4587, pp. 975 - 977
DOI: 10.1126/science.6823559
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Articles

Science, Vol 219, Issue 4587, 975-977
Copyright © 1983 by American Association for the Advancement of Science

articles

Transfusions of whole blood prevent spontaneous diabetes mellitus in the BB/W rat

AA Rossini, JP Mordes, AM Pelletier, and AA Like

Weekly transfusions of whole blood from a nondiabetic subline of BB/W rats reduced the incidence of diabetes in susceptible BB/W rats from 39 to 0 percent and the incidence of pancreatic insulitis from 64 to 6 percent. Responsiveness of lymphocytes to concanavalin A was found to be low in rats with diabetes or insulitis. Transfusion restored concanavalin A responsiveness to levels observed in control rats free of diabetes or insulitis. These data suggest that whole blood alters the course of autoimmune BB/W rat diabetes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Regulatory CD4+ T Cell Subset in the BB Rat Model of Autoimmune Diabetes Expresses Neither CD25 Nor Foxp3.
J.-L. Hillebrands, B. Whalen, J. T. J. Visser, J. Koning, K. D. Bishop, J. Leif, J. Rozing, J. P. Mordes, D. L. Greiner, and A. A. Rossini (2006)
J. Immunol. 177, 7820-7832
   Abstract »    Full Text »    PDF »
Autoimmune Diabetes and the Circle of Tolerance.
A. A. Rossini (2004)
Diabetes 53, 267-275
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The Pathophysiology of Diabetes Mellitus: An Update.
C. G. Hernandez (1989)
The Diabetes Educator 15, 162-169
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Effects of cyclosporine immunosuppression in insulin-dependent diabetes mellitus of recent onset.
C. Stiller, J Dupre, M Gent, M. Jenner, P. Keown, A Laupacis, R Martell, N. Rodger, B von Graffenried, and B. Wolfe (1984)
Science 223, 1362-1367
   Abstract »    PDF »


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