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Science 18 February 1983:
Vol. 219. no. 4586, pp. 881 - 883
DOI: 10.1126/science.6401866
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Articles

Science, Vol 219, Issue 4586, 881-883
Copyright © 1983 by American Association for the Advancement of Science

articles

Human brain tumor--derived cell lines: growth rate reduced by human fibroblast interferon

AW Cook, WA Carter, F Nidzgorski, and L Akhtar

The biological response modifier human beta-interferon had pronounced antigrowth effects on various histologic types of human brain tumor cells but no effects on a nontransformed cell line, MRC-5. The cultures of brain tumor cells showed severe alterations indicative of cell injury and death after exposure to beta-interferon for 2 to 6 days. Similar results were obtained with cells freshly explanted from human brain tumors. The results indicate that it may be possible to use fresh, explanted tumor tissue to identify patients who might benefit from therapy with beta-interferon.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Efficient Inhibition of In Vivo Human Malignant Glioma Growth and Angiogenesis by Interferon-{beta} Treatment at Early Stage of Tumor Development.
Y.-K. Hong, D.-S. Chung, Y.-A. Joe, Y.-J. Yang, K.-M. Kim, Y.-S. Park, W. K. A. Yung, and J.-K. Kang (2000)
Clin. Cancer Res. 6, 3354-3360
   Abstract »    Full Text »
Immune and non-immune actions of interferon-{beta}-1b on primary human neural cells.
J McLaurin, J. Antel, and V. Yong (1995)
Multiple Sclerosis 1, 10-19
   Abstract »    PDF »


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