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Science 18 February 1983:
Vol. 219. no. 4586, pp. 862 - 864
DOI: 10.1126/science.6600520
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Articles

Science, Vol 219, Issue 4586, 862-864
Copyright © 1983 by American Association for the Advancement of Science

articles

Gene reactivation in erythrocytes: nuclear transplantation in oocytes and eggs of Rana

MA DiBerardino and NJ Hoffner

Adult erythrocyte nuclei of Rana, transplanted and incubated in the cytoplasm of maturing oocytes, direct matured oocytes to form swimming tadpoles. These results demonstrate that nuclei of noncycling and terminally differentiated erythrocytes contain the genes to specify tadpole development, and conditioning these nuclei in the cytoplasm of oocytes leads to a widespread reactivation of dormant genes.


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