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Science 18 February 1983:
Vol. 219. no. 4586, pp. 851 - 853
DOI: 10.1126/science.6186025
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Articles

Science, Vol 219, Issue 4586, 851-853
Copyright © 1983 by American Association for the Advancement of Science

articles

Tumor suppression with a combination of alpha-difluoromethyl ornithine and interferon

PS Sunkara, NJ Prakash, GD Mayer, and A Sjoerdsma

alpha-Difluoromethyl ornithine and mouse type 1 interferon, when administered simultaneously, were highly toxic to B16 melanoma cells in culture. Oral administration of alpha-difluoromethyl ornithine suppressed B16 melanoma development in mice 85 percent whereas interferon given subcutaneously inhibited tumor growth only 24 percent. Total or near total suppression of tumor growth was observed in mice receiving both treatments.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Effects of the Irreversible Ornithine Decarboxylase Inhibitor, {alpha}-Difluoromethylornithine, Aflatoxin B1, and Choline Deficiency on Hepatocarcinogenesis.
D. Sondergaard, F. Taylor, and P. M. Newberne (1985)
Toxicol Pathol 13, 36-49
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