Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 11 February 1983:
Vol. 219. no. 4585, pp. 666 - 671
DOI: 10.1126/science.6572017
Prev | Table of Contents | Next

Articles

Science, Vol 219, Issue 4585, 666-671
Copyright © 1983 by American Association for the Advancement of Science

articles

Protein engineering

KM Ulmer

The prospects for protein engineering, including the roles of x-ray crystallography, chemical synthesis of DNA, and computer modelling of protein structure and folding, are discussed. It is now possible to attempt to modify many different properties of proteins by combining information on crystal structure and protein chemistry with artificial gene synthesis. Such techniques offer the potential for altering protein structure and function in ways not possible by any other method.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Determination of the Role of the Carboxyl-terminal Leucine-122 in FMN-binding Protein by Mutational and Structural Analysis.
M. Kitamura, K. Terakawa, H. Inoue, T. Hayashida, K. Suto, Y. Morimoto, N. Yasuoka, N. Shibata, and Y. Higuchi (2007)
J. Biochem. 141, 459-468
   Abstract »    Full Text »    PDF »
Translated products of tandem microgene repeats exhibit diverse properties also seen in natural proteins.
K. Shiba, T. Shirai, T. Honma, and T. Noda (2003)
Protein Eng. Des. Sel. 16, 57-63
   Abstract »    Full Text »    PDF »
Crystal structures of mutants of Thermus thermophilus IPMDH adapted to low temperatures.
R. Hirose, T. Suzuki, H. Moriyama, T. Sato, A. Yamagishi, T. Oshima, and N. Tanaka (2001)
Protein Eng. Des. Sel. 14, 81-84
   Abstract »    Full Text »    PDF »
Toward a science of metabolic engineering.
J. Bailey (1991)
Science 252, 1668-1675
   Abstract »    PDF »
Tinkering with enzymes: what are we learning?.
J. Knowles (1987)
Science 236, 1252-1258
   Abstract »    PDF »
Biotechnology in Food Production and Processing.
D. Knorr and A. J. Sinskey (1985)
Science 229, 1224-1229
   Abstract »    PDF »
The mechanisms of irreversible enzyme inactivation at 100C.
T. Ahern and A. Klibanov (1985)
Science 228, 1280-1284
   Abstract »    PDF »
Disulfide bond engineered into T4 lysozyme: stabilization of the protein toward thermal inactivation.
L. Perry and R Wetzel (1984)
Science 226, 555-557
   Abstract »    PDF »
Enzymatic catalysis in organic media at 100 degrees C.
A Zaks and A. Klibanov (1984)
Science 224, 1249-1251
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)