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Science 4 February 1983:
Vol. 219. no. 4584, pp. 501 - 503
DOI: 10.1126/science.6186022
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Articles

Science, Vol 219, Issue 4584, 501-503
Copyright © 1983 by American Association for the Advancement of Science

articles

Drug-induced alterations of cytokeratin organization in cultured epithelial cells

LW Knapp, WM O'Guin, and RH Sawyer

The distribution of keratin intermediate filaments, previously considered static in organization and imperturbable by conventional drugs used to alter the structure and organization of the cytoskeleton, can be altered significantly by treatment with colchicine and cytochalasin D. The loss of microfilaments and microtubules converts the keratin cytoskeleton from a branching, even distribution to a series of starlike structures whose filaments are maintained by multiple membrane attachment sites. These findings provide a means for manipulating cytokeratin organization to investigate the role of keratins in cytoskeletal structure and function.


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The Apical Submembrane Cytoskeleton Participates in the Organization of the Apical Pole in Epithelial Cells.
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The network organization and the phosphorylation of cytokeratins are concomitantly modified by forskolin in the enterocyte-like differentiated Caco-2 cell line.
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Vimentin's tail interacts with actin-containing structures in vivo.
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Hemidesmosomes in the epithelial cell line 804G: their fate during wound closure, mitosis and drug induced reorganization of the cytoskeleton.
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Molecular genetics of epidermolysis bullosa.
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