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Science 4 February 1983:
Vol. 219. no. 4584, pp. 493 - 495
DOI: 10.1126/science.6681676

Articles

Science, Vol 219, Issue 4584, 493-495
Copyright © 1983 by American Association for the Advancement of Science


articles

Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells

I Spector, NR Shochet, Y Kashman, and A Groweiss

Two toxins, latrunculins A and B, which contain a new class of 16- and 14-membered marine macrolides attached to the rare 2-thiazolidinone moiety, were purified recently from the Red Sea sponge Latrunculia magnifica. The effects of these toxins on cultured mouse neuroblastoma and fibroblast cells have been evaluated. In both types of cells, submicromolar toxin concentrations rapidly induce striking changes in cell morphology that are reversible upon removal of the toxin. Immunofluorescence studies with antibodies specific for cytoskeletal proteins reveal that the toxins cause major alterations in the organization of microfilaments without obvious effects on the organization of the microtubular system.


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Latrunculins' Effects on Intraocular Pressure, Aqueous Humor Flow, and Corneal Endothelium.
J. A. Peterson, B. Tian, J. W. McLaren, W. C. Hubbard, B. Geiger, and P. L. Kaufman (2000)
Invest. Ophthalmol. Vis. Sci. 41, 1749-1758
   Abstract »    Full Text »
Zebrafish vasa RNA but Not Its Protein Is a Component of the Germ Plasm and Segregates Asymmetrically before Germline Specification.
H. Knaut, F. Pelegri, K. Bohmann, H. Schwarz, and C. Nusslein-Volhard (2000)
J. Cell Biol. 149, 875-888
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The Role of the Cooh Terminus of Sec2p in the Transport of Post-Golgi Vesicles.
N. B. Elkind, C. Walch-Solimena, and P. J. Novick (2000)
J. Cell Biol. 149, 95-110
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A Role for the Actin Cytoskeleton in the Initiation and Maintenance of Store-mediated Calcium Entry in Human Platelets. EVIDENCE FOR CONFORMATIONAL COUPLING.
J. A. Rosado, S. Jenner, and S. O. Sage (2000)
J. Biol. Chem. 275, 7527-7533
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Inactivation of P2X2 purinoceptors by divalent cations.
S. Ding and F. Sachs (2000)
J. Physiol. 522, 199-214
   Abstract »    Full Text »    PDF »
Distinct Roles of Synaptic and Extrasynaptic NMDA Receptors in Excitotoxicity.
R. Sattler, Z. Xiong, W.-Y. Lu, J. F. MacDonald, and M. Tymianski (2000)
J. Neurosci. 20, 22-33
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