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Science 4 February 1983: Vol. 219. no. 4584, pp. 493 - 495 DOI: 10.1126/science.6681676
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Articles
Science, Vol 219, Issue 4584, 493-495
Copyright © 1983 by American Association for the Advancement of Science
Latrunculins: novel marine toxins that disrupt microfilament organization in cultured cells
I Spector,
NR Shochet,
Y Kashman,
and
A Groweiss
Two toxins, latrunculins A and B, which contain a new class of 16- and 14-membered marine macrolides attached to the rare 2-thiazolidinone moiety, were purified recently from the Red Sea sponge Latrunculia magnifica. The effects of these toxins on cultured mouse neuroblastoma and fibroblast cells have been evaluated. In both types of cells, submicromolar toxin concentrations rapidly induce striking changes in cell morphology that are reversible upon removal of the toxin. Immunofluorescence studies with antibodies specific for cytoskeletal proteins reveal that the toxins cause major alterations in the organization of microfilaments without obvious effects on the organization of the microtubular system.
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- I. Hwang and J. Sprent (2001)
J. Immunol.
166, 5099-5107
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- Translocation of the B Cell Antigen Receptor into Lipid Rafts Reveals a Novel Step in Signaling.
- P. C. Cheng, B. K. Brown, W. Song, and S. K. Pierce (2001)
J. Immunol.
166, 3693-3701
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- Membrane Lipid Rafts Are Necessary for the Maintenance of the {alpha}7 Nicotinic Acetylcholine Receptor in Somatic Spines of Ciliary Neurons.
- J. L. Bruses, N. Chauvet, and U. Rutishauser (2001)
J. Neurosci.
21, 504-512
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- The Actin-Driven Movement and Formation of Acetylcholine Receptor Clusters.
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J. Cell Biol.
150, 1321-1334
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- Regulation of Somatodendritic GABAA Receptor Channels in Rat Hippocampal Neurons: Evidence for a Role of the Small GTPase Rac1.
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J. Neurosci.
20, 6743-6751
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- Role of MMM1 in Maintaining Mitochondrial Morphology in Neurospora crassa.
- H. Prokisch, W. Neupert, and B. Westermann (2000)
Mol. Biol. Cell
11, 2961-2971
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- Disruption of actin impedes transmitter release in snake motor terminals.
- J. C Cole, B. R S Villa, and R. S Wilkinson (2000)
J. Physiol.
525, 579-586
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- Latrunculins' Effects on Intraocular Pressure, Aqueous Humor Flow, and Corneal Endothelium.
- J. A. Peterson, B. Tian, J. W. McLaren, W. C. Hubbard, B. Geiger, and P. L. Kaufman (2000)
Invest. Ophthalmol. Vis. Sci.
41, 1749-1758
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- Zebrafish vasa RNA but Not Its Protein Is a Component of the Germ Plasm and Segregates Asymmetrically before Germline Specification.
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J. Cell Biol.
149, 875-888
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- The Role of the Cooh Terminus of Sec2p in the Transport of Post-Golgi Vesicles.
- N. B. Elkind, C. Walch-Solimena, and P. J. Novick (2000)
J. Cell Biol.
149, 95-110
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- A Role for the Actin Cytoskeleton in the Initiation and Maintenance of Store-mediated Calcium Entry in Human Platelets. EVIDENCE FOR CONFORMATIONAL COUPLING.
- J. A. Rosado, S. Jenner, and S. O. Sage (2000)
J. Biol. Chem.
275, 7527-7533
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- Inactivation of P2X2 purinoceptors by divalent cations.
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522, 199-214
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- Distinct Roles of Synaptic and Extrasynaptic NMDA Receptors in Excitotoxicity.
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J. Neurosci.
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