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Science 28 January 1983:
Vol. 219. no. 4583, pp. 416 - 419
DOI: 10.1126/science.6849143
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Articles

Science, Vol 219, Issue 4583, 416-419
Copyright © 1983 by American Association for the Advancement of Science

articles

Nigral transplants reinnervating the dopamine-depleted neostriatum can sustain intracranial self-stimulation

PJ Fray, SB Dunnett, SD Iversen, A Bjorklund, and U Stenevi

Transplants of embryonic substantia nigra reinnervated the striatum and were able to sustain intracranial self-stimulation in rats with brain lesions induced by 6-hydroxydopamine. Dopaminergic drugs and alterations in current intensity produced typical changes in response rates. Animals with electrodes implanted into cortical grafts or into the denervated striatum failed to exhibit self-stimulation. These findings suggest that transplanted dopamine neurons convey specific, temporally organized information axonally to the striatum.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
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