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Science 28 January 1983:
Vol. 219. no. 4583, pp. 408 - 410
DOI: 10.1126/science.6849141
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Articles

Science, Vol 219, Issue 4583, 408-410
Copyright © 1983 by American Association for the Advancement of Science

articles

Methyl 4,6-dichloro-4,6-dideoxy-alpha-D-galactopyranoside: an inhibitor of sweet taste responses in gerbils

W Jakinovich Jr

The sugar methyl 4,6-dichloro-4,6-dideoxy-alpha-D-galactopyranoside (DiCl-gal) is a new type of inhibitor of the gerbil's electrophysiological taste response to sucrose or saccharin. Saturated solutions of this compound alone barely stimulate the gerbil's taste nerve. But, when mixed with sucrose or saccharin, DiCl-gal suppresses the gerbil's taste response to these two sweeteners. In contrast, when mixed with sodium chloride or hydrochloric acid, DiCl-gal does not affect the taste responses to these compounds. However, unlike other inhibitors of sweet taste, the DiCl-gal taste suppression is short-lived and occurs only when the inhibitor is combined with the sweetener.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Selective Inhibition of Sweetness by the Sodium Salt of {+/-}2-(4-Methoxyphenoxy)propanoic Acid.
S. S. Schiffman, B. J. Booth, E. A. Sattely-Miller, B. G. Graham, and K. M. Gibes (1999)
Chem Senses 24, 439-447
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