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Science 21 January 1983:
Vol. 219. no. 4582, pp. 303 - 306
DOI: 10.1126/science.6294830
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Articles

Science, Vol 219, Issue 4582, 303-306
Copyright © 1983 by American Association for the Advancement of Science

articles

Protein kinase injection reduces voltage-dependent potassium currents

DL Alkon, J Acosta-Urquidi, J Olds, G Kuzma, and JT Neary

Intracellular iontophoretic injection of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase increased input resistance and decreased a delayed voltage-dependent K+ current of the type B photoreceptor in the nudibranch Hermissenda crassicornis to a greater extent than an early, rapidly inactivating K+ current (IA). This injection also enhanced the long-lasting depolarization of type B cells after a light step. These findings suggest the involvement of cyclic adenosine monophosphate-dependent phosphorylation in the differential regulation of photoreceptor K+ currents particularly during illumination. On the other hand, conditioning-induced changes in IA may also be regulated by a different type of phosphorylation (for example, Ca2+-dependent).


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