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Science 14 January 1983:
Vol. 219. no. 4581, pp. 195 - 197
DOI: 10.1126/science.6849132
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Articles

Science, Vol 219, Issue 4581, 195-197
Copyright © 1983 by American Association for the Advancement of Science

articles

Myasthenic globulin enhances the loss of acetylcholine receptor clusters

S Bursztajn, JL McManaman, SB Elias, and SH Appel

Acetylcholine receptors are present in the sarcolemma of cultured skeletal muscle myotubes either as large clusters or in a diffuse distribution. Both the clustered and diffuse acetylcholine receptors are potentially removable from the membrane. Treatment of myotubes with globulin from patients with myasthenia gravis causes the loss of acetylcholine receptor clusters and the concomitant appearance of acetylcholine receptor microaggregates. The rate of acetylcholine receptor cluster loss is greater than the rate of acetylcholine receptor degradation, indicating that acetylcholine receptors are disrupted from clusters to form microaggregates before being removed from the plasma membrane.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Nicotinic acetylcholine receptor is internalized via a Rac-dependent, dynamin-independent endocytic pathway.
S. Kumari, V. Borroni, A. Chaudhry, B. Chanda, R. Massol, S. Mayor, and F. J. Barrantes (2008)
J. Cell Biol. 181, 1179-1193
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