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Science 14 January 1983:
Vol. 219. no. 4581, pp. 189 - 191
DOI: 10.1126/science.6129700
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Articles

Science, Vol 219, Issue 4581, 189-191
Copyright © 1983 by American Association for the Advancement of Science

articles

Immunoreactive dynorphin-(1-8) and corticotropin- releasing factor in subpopulation of hypothalamic neurons

KA Roth, E Weber, JD Barchas, D Chang, and JK Chang

Immunoreactive corticotropin-releasing factor (CRF) and dynorphin-(I-8) were visualized in rat hypothalamus by immunohistofluorescence with specific antibodies. In brains from colchicine-treated, adrenalectomized rats, neuronal perikarya with immunoreactive CRF were observed in the paraventricular nucleus of the hypothalamus. The CRF occurred together with the dynorphin-(1-8). However, the CRF immunoreactivity occurred only in a subpopulation of the dynorphin-(1-8) immunoreactive cells. These findings suggest that there may be a functional interrelationship of CRF with dynorphin-related opioid peptides and provide further evidence that neurons may contain more than one bioactive substance.


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