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Science 7 January 1983:
Vol. 219. no. 4580, pp. 65 - 67
DOI: 10.1126/science.6849117
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Articles

Science, Vol 219, Issue 4580, 65-67
Copyright © 1983 by American Association for the Advancement of Science

articles

Guanosine triphosphate activation of brain adenylate cyclase: enhancement by long-term antidepressant treatment

DB Menkes, MM Rasenick, MA Wheeler, and MW Bitensky

Activation of adenylate cyclase by a stable guanosine 5'-triphosphate analog was augmented in brain membrane preparations from rats treated on a long-term basis with tricyclic antidepressants or electroconvulsive shock. These treatments may facilitate cyclase activation by promoting the interaction of the regulatory and catalytic subunits of the enzyme. This finding suggests a possible mechanism for the changes in sensitivity to various neurotransmitters seen after antidepressant administration.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Postmortem Brain Tissue of Depressed Suicides Reveals Increased Gs{alpha} Localization in Lipid Raft Domains Where It Is Less Likely to Activate Adenylyl Cyclase.
R. J. Donati, Y. Dwivedi, R. C. Roberts, R. R. Conley, G. N. Pandey, and M. M. Rasenick (2008)
J. Neurosci. 28, 3042-3050
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A Sex-Specific Role of Type VII Adenylyl Cyclase in Depression.
L. M. Hines, P. L. Hoffman, S. Bhave, L. Saba, A. Kaiser, L. Snell, I. Goncharov, L. LeGault, M. Dongier, B. Grant, et al. (2006)
J. Neurosci. 26, 12609-12619
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{beta}-Arrestin-1 Levels: Reduced in Leukocytes of Patients With Depression and Elevated by Antidepressants in Rat Brain.
S. Avissar, A. Matuzany-Ruban, K. Tzukert, and G. Schreiber (2004)
Am J Psychiatry 161, 2066-2072
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Chronic Treatment of C6 Glioma Cells with Antidepressant Drugs Results in a Redistribution of Gsalpha.
R. J. Donati, C. Thukral, and M. M. Rasenick (2001)
Mol. Pharmacol. 59, 1426-1432
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Regulation of Signal Transduction Pathways and Gene Expression by Mood Stabilizers and Antidepressants.
G. Chen, K. A. Hasanat, J. M. Bebchuk, G. J. Moore, D. Glitz, and H. K. Manji (1999)
Psychosom Med 61, 599-617
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{alpha}2-Adrenoceptor--Mediated Inhibition of Platelet Adenylate Cyclase and Induction of Aggregation in Major Depression: Effect of Long-term Cyclic Antidepressant Drug Treatment.
J. A. Garcia-Sevilla, D. Pardro, M. T. Giralt, J. Guimon, and P. Areso (1990)
Arch Gen Psychiatry 47, 125-132
   Abstract »    PDF »
Platelet {alpha}2-Adrenergic Receptors in Depression.
M. S. Kafka and S. M. Paul (1986)
Arch Gen Psychiatry 43, 91-95
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