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Science 7 January 1983:
Vol. 219. no. 4580, pp. 56 - 58
DOI: 10.1126/science.6336851
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Articles

Science, Vol 219, Issue 4580, 56-58
Copyright © 1983 by American Association for the Advancement of Science

articles

Lines of T lymphocytes induce or vaccinate against autoimmune arthritis

J Holoshitz, Y Naparstek, A Ben-Nun, and IR Cohen

The pathophysiology of autoimmune arthritis was studied by selecting and isolating lines of effector T lymphocytes from rats administered an arthritogenic dose of Mycobacterium tuberculosis in complete Freund's adjuvant to induce adjuvant arthritis. Irradiated rats were intravenously inoculated with a cell line characterized by proliferative reactivity to Mycobacterium tuberculosis and, to a lesser degree, to rat collagen type II. This produced arthritis in all the irradiated rats. Nonirradiated recipients failed to develop arthritis. However, such rats, and those recovering from cell-mediated arthritis, were resistant to subsequent attempts to induce adjuvant arthritis. Lines of T lymphocytes selected for responsiveness to other antigens had no effect. Therefore, a line of T lymphocytes responsive to bacteria or to collagen type II could either induce autoimmune arthritis or serve as an agent of vaccination against it.


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