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Science 24 December 1982:
Vol. 218. no. 4579, pp. 1334 - 1337
DOI: 10.1126/science.7146917
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Articles

Science, Vol 218, Issue 4579, 1334-1337
Copyright © 1982 by American Association for the Advancement of Science

articles

Monoclonal anitbodies in the lymphatics: toward the diagnosis and therapy of tumor metastases

JN Weinstein, RJ Parker, AM Keenan, SK Dower, HC Morse and SM Sieber

Monoclonal antibodies subcutaneously injected into mice track to regional lymph nodes and specifically label target cells there. The lymphatic route of administration can be expected to provide much higher sensitivity, higher target-to-background ratio, faster localization, and lower toxicity than the intravenous route when the aim is to diagnose or treat tumor metastases or lymphoma in the lymph nodes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dual-Labeled Trastuzumab-Based Imaging Agent for the Detection of Human Epidermal Growth Factor Receptor 2 Overexpression in Breast Cancer.
L. Sampath, S. Kwon, S. Ke, W. Wang, R. Schiff, M. E. Mawad, and E. M. Sevick-Muraca (2007)
J. Nucl. Med. 48, 1501-1510
   Abstract »    Full Text »    PDF »
Monoclonal antibodies in the lymphatics: selective delivery to lymph node metastases of a solid tumor.
J. Weinstein, M. Steller, A. Keenan, D. Covell, M. Key, S. Sieber, R. Oldham, K. Hwang, and R. Parker (1983)
Science 222, 423-426
   Abstract »    PDF »


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