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Science 24 December 1982:
Vol. 218. no. 4579, pp. 1332 - 1334
DOI: 10.1126/science.6293059
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Articles

Science, Vol 218, Issue 4579, 1332-1334
Copyright © 1982 by American Association for the Advancement of Science

articles

Benzodiazepine receptor-mediated experimental "anxiety" in primates

PT Ninan, TM Insel, RM Cohen, JM Cook, P Skolnick, and SM Paul

The ethyl ester of beta-carboline-3-carboxylic acid has a high affinity for benzodiazepine receptors in the brain. In the rhesus monkey this substance produces an acute behavioral syndrome characterized by dramatic elevations in heart rate, blood pressure, plasma cortisol, and catecholamines. The effects are blocked by benzodiazepines and the specific benzodiazepine receptor antagonist Ro 15-1788. The benzodiazepine receptor may consist of several subsites or functional domains that independently recognize agonist, antagonists, or "active" antagonists such as beta-carboline-3-carboxylic acid ethyl ester. These results suggest that the benzodiazepine receptor is involved in both the affective and physiological manifestations of anxiety, and that the administration of beta-carboxylic acid ethyl ester to monkeys may provide a reliable and reproducible animal model of human anxiety.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Inhibition by venlafaxine of the increase in norepinephrine output in rat prefrontal cortex elicited by acute stress or by the anxiogenic drug FG 7142.
L. Dazzi, V. Vignone, E. Seu, S. Ladu, G. Vacca, and G. Biggio (2002)
J Psychopharmacol 16, 125-131
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What do brain imaging studies tell us about anxiety disorders?.
A. L. Malizia (1999)
J Psychopharmacol 13, 372-378
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Reduced Benzodiazepine Sensitivity in Panic Disorder.
P. P. Roy-Byrne, D. S. Cowley, D. J. Greenblatt, R. I. Shader, and D. Hommer (1990)
Arch Gen Psychiatry 47, 534-538
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Cortisol and Sodium Lactate--Induced Panic.
E. Hollander, M. R. Liebowitz, J. M. Gorman, B. Cohen, A. Fyer, and D. F. Klein (1989)
Arch Gen Psychiatry 46, 135-140
   Abstract »    PDF »
Pharmacologic Treatment of Psychiatric and Neurodevelopmental Disorders in Children and Adolescents (Part 3).
K. D. McDaniel (1986)
Clinical Pediatrics 25, 198-204
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A Benzodiazepine Receptor--Mediated Model of Anxiety: Studies in Nonhuman Primates and Clinical Implications.
T. R. Insel, P. T. Ninan, J. Aloi, D. C. Jimerson, P. Skolnick, and S. M. Paul (1984)
Arch Gen Psychiatry 41, 741-750
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)