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Science 24 December 1982:
Vol. 218. no. 4579, pp. 1323 - 1325
DOI: 10.1126/science.6293058
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Articles

Science, Vol 218, Issue 4579, 1323-1325
Copyright © 1982 by American Association for the Advancement of Science

articles

Yeast mating pheromone activates mammalian gonadotrophs: evolutionary conservation of a reproductive hormone?

E Loumaye, J Thorner, and KJ Catt

alpha-Factor, a tridecapeptide mating pheromone of yeast (Saccharomyces cerevisiae), has extensive sequence homology with the hypothalamic decapeptide gonadotropin-releasing hormone (GnRH). Both synthetic and natural preparations of alpha-mating factor were found to bind specifically to rat pituitary GnRH receptors and to stimulate the release of luteinizing hormone from cultured gonadotrophs. The ability of the yeast pheromone to reproduce the biological actions of GnRH in the mammalian pituitary gland indicates that the structural and functional properties of GnRH-related peptides may have been highly conserved during evolution.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Human placental GnRH-like factors: parallel displacement in GnRH immuno- and receptor-binding assays can be caused by degradation of radiolabelled GnRH tracers.
T.A. Bramley, H.P. Boyle, and G.S. Menzies (1999)
Mol. Hum. Reprod. 5, 1095-1106
   Abstract »    Full Text »    PDF »
Brain peptides: what, where, and why?.
D. Krieger (1983)
Science 222, 975-985
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)