Related Content
Search Google Scholar for:
|
|
Science 24 December 1982:
Vol. 218. no. 4579, pp. 1319 - 1321
DOI: 10.1126/science.7146913
|
|
Articles
Science, Vol 218, Issue 4579, 1319-1321
Copyright © 1982 by American Association for the Advancement of Science
Mouse c-myc oncogene is located on chromosome 15 and translocated to chromosome 12 in plasmacytomas
S Crews,
R Barth,
L Hood,
J Prehn,
and
K Calame
Hybridization studies with viral oncogene probes indicate that c-myc, the cellular gene homologous to the transforming gene of avian myelocytomatosis virus, resides on mouse chromosome 15 and in many plasmacytomas is translocated to the antibody heavy chain gene locus on chromosome 12. The transcriptional orientation of the translocated c-myc sequence is opposite the orientation of the adjacent C alpha gene that codes for the heavy chain of immunoglobulin A. The translocated c-myc sequence is not the same oncogene detected in urine plasmacytomas by the NIH-3T3 cell transformation assay.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- A role for AID in chromosome translocations between c-myc and the IgH variable region.
- Y. Dorsett, D. F. Robbiani, M. Jankovic, B. Reina-San-Martin, T. R. Eisenreich, and M. C. Nussenzweig (2007)
J. Exp. Med.
204, 2225-2232
| Abstract »
| Full Text »
| PDF »
- Genetics and Cytogenetics of Multiple Myeloma: A Workshop Report.
- R. Fonseca, B. Barlogie, R. Bataille, C. Bastard, P. L. Bergsagel, M. Chesi, F. E. Davies, J. Drach, P. R. Greipp, I. R. Kirsch, et al. (2004)
Cancer Res.
64, 1546-1558
| Abstract »
| Full Text »
| PDF »
- Genomic abnormalities in monoclonal gammopathy of undetermined significance.
- R. Fonseca, R. J. Bailey, G. J. Ahmann, S. V. Rajkumar, J. D. Hoyer, J. A. Lust, R. A. Kyle, M. A. Gertz, P. R. Greipp, and G. W. Dewald (2002)
Blood
100, 1417-1424
| Abstract »
| Full Text »
| PDF »
- Anti-IgM-mediated Regulation of c-myc and Its Possible Relationship to Apoptosis.
- J. S. Kaptein, C.-K. E. Lin, C. L. Wang, T. T. Nguyen, C. I. Kalunta, E. Park, F.-S. Chen, and P. M. Lad (1996)
J. Biol. Chem.
271, 18875-18884
| Abstract »
| Full Text »
| PDF »
- Genetic rearrangements and gene amplification in Escherichia coli: DNA sequences at the junctures of amplified gene fusions..
- S K Whoriskey, V H Nghiem, P M Leong, J M Masson, and J H Miller (1987)
Genes & Dev.
1, 227-237
| Abstract »
| PDF »
- X-ray--induced breakage and rejoining of human interphase chromosomes.
- M. Cornforth and J. Bedford (1983)
Science
222, 1141-1143
| Abstract »
| PDF »
- Translocations among antibody genes in human cancer.
- P Leder, J Battey, G Lenoir, C Moulding, W Murphy, H Potter, T Stewart, and R Taub (1983)
Science
222, 765-771
| Abstract »
| PDF »
- Cellular oncogenes and multistep carcinogenesis.
- H Land, L. Parada, and R. Weinberg (1983)
Science
222, 771-778
| Abstract »
| PDF »
- Identification of the c-myc oncogene product in normal and malignant B cells.
- A Giallongo, E Appella, R Ricciardi, G Rovera, and C. Croce (1983)
Science
222, 430-432
| Abstract »
| PDF »
- Normal cells of patients with high cancer risk syndromes lack transforming activity in the NIH/3T3 transfection assay.
- S. Needleman, Y Yuasa, S Srivastava, and S. Aaronson (1983)
Science
222, 173-175
| Abstract »
| PDF »
- Genetic mapping of the mouse proto-oncogene c-sis to chromosome 15.
- C. Kozak, J. Sears, and M. Hoggan (1983)
Science
221, 867-869
| Abstract »
| PDF »
- Transcriptional enhancer elements in the mouse immunoglobulin heavy chain locus.
- M Mercola, X. Wang, J Olsen, and K Calame (1983)
Science
221, 663-665
| Abstract »
| PDF »
- Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor.
- R. Doolittle, M. Hunkapiller, L. Hood, S. Devare, K. Robbins, S. Aaronson, and H. Antoniades (1983)
Science
221, 275-277
| Abstract »
| PDF »
- DNA rearrangement and altered RNA expression of the c-myb oncogene in mouse plasmacytoid lymphosarcomas.
- J. Mushinski, M Potter, Bauer SR, and E. Reddy (1983)
Science
220, 795-798
| Abstract »
| PDF »
|
|
