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Science 24 December 1982:
Vol. 218. no. 4579, pp. 1315 - 1317
DOI: 10.1126/science.6293056
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Articles

Science, Vol 218, Issue 4579, 1315-1317
Copyright © 1982 by American Association for the Advancement of Science

articles

Eukaryotic transcriptional regulation and chromatin-associated protein phosphorylation by cyclic AMP

GH Murdoch and MG Rosenfeld

Cyclic adenosine monophosphate (AMP) analogs or agents that increase intracellular cyclic AMP rapidly stimulate transcription of the prolactin gene in a line of cultured rat pituitary cells. This effect is correlated with the phosphorylation of a chromatin-associated basic protein designated BPR. These data are consistent with the postulate that increased intracellular cyclic AMP concentrations induce rapid transcriptional effects on specific genes in eukaryotes, mediated by direct or indirect phosphorylation of a specific chromatin-associated protein or proteins.


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