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Science 24 December 1982:
Vol. 218. no. 4579, pp. 1313 - 1315
DOI: 10.1126/science.6897299
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Articles

Science, Vol 218, Issue 4579, 1313-1315
Copyright © 1982 by American Association for the Advancement of Science

articles

Diphenylhydantoin: an alternative ligand of a glucocorticoid receptor affecting prostaglandin generation in A/J mice

M Katsumata, C Gupta, MK Baker, CE Sussdorf, and AS Goldman

Evidence for the binding of 5,5-diphenylhydantoin and glucocorticoids to a common receptor is presented for pulmonary and hepatic cytosols and thymocytes of A/J female mice. The 5,5-diphenylhydantoin-protein complex is absorbed by DNA cellulose, and is incorporated into nuclei, 5,5-Diphenylhydantoin, like glucocorticoids, inhibits the production of prostaglandins in thymocytes. Thus a common receptor is probably responsible for the inhibitory and teratogenic effects of these drugs.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Nonsteroidal Glucocorticoid Receptor Antagonist.
J. N. Miner, C. Tyree, J. Hu, E. Berger, K. Marschke, M. Nakane, M. J. Coghlan, D. Clemm, B. Lane, and J. Rosen (2003)
Mol. Endocrinol. 17, 117-127
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Science. ISSN 0036-8075 (print), 1095-9203 (online)