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Science 10 December 1982:
Vol. 218. no. 4577, pp. 1117 - 1119
DOI: 10.1126/science.7146897
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Articles

Science, Vol 218, Issue 4577, 1117-1119
Copyright © 1982 by American Association for the Advancement of Science

articles

Rhodamine-123 selectively reduces clonal growth of carcinoma cells in vitro

SD Bernal, TJ Lampidis, IC Summerhayes, and LB Chen

Rhodamine-123, a cationic laser dye, markedly reduced the clonal growth of carcinoma cells but had little effect on nontumorigenic epithelial cells in vitro. This selective inhibitory effect of Rhodamine-123 on some carcinomas is unusual since known anticancer drugs, such as arabinosyl cytosine and methotrexate, have not been shown to exhibit such selectivity in vitro.


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Cloning and Identification of Hepatocellular Carcinoma Down-regulated Mitochondrial Carrier Protein, a Novel Liver-specific Uncoupling Protein.
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Synergistic Activity of the N-Terminal Peptide of Human Lactoferrin and Fluconazole against Candida Species.
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Candidacidal Activities of Human Lactoferrin Peptides Derived from the N Terminus.
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Measurement of Intracellular Calcium.
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Physiol Rev 79, 1089-1125
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Inhibition of Rat Colon Tumor Isograft Growth With Dequalinium Chloride.
R. Bleday, M. J. Weiss, R. R. Salem, R. E. Wilson, L. B. Chen, and G. Steele Jr (1986)
Arch Surg 121, 1272-1275
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Anticarcinoma activity in vivo of rhodamine 123, a mitochondrial-specific dye.
S. Bernal, T. Lampidis, R. McIsaac, and L. Chen (1983)
Science 222, 169-172
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