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Science 10 December 1982:
Vol. 218. no. 4577, pp. 1082 - 1088
DOI: 10.1126/science.218.4577.1082
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Articles

Pathfinding by Peripheral Pioneer Neurons in Grasshoppers

David Bentley 1 and Haig Keshishian 2

1 Chairperson in the Department of Zoology and Neurobiology Group, University of California, Berkeley 94720
2 Graduate student in the Department of Zoology and Neurobiology Group, University of California, Berkeley 94720

Grasshopper neurons accurately project axons across long distances between peripheral structures and the central nervous system. Nerve-trunk pathways followed by these axons are established early in embryogenesis by pioneer neurons. Growth cones from the first pioneers navigate along a chain of cells to the CNS. The placement of these cells may constitute the initial guidance mechanism underlying long-distance pathfinding.


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