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Science 26 November 1982:
Vol. 218. no. 4575, pp. 900 - 901
DOI: 10.1126/science.6291152
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Articles

Science, Vol 218, Issue 4575, 900-901
Copyright © 1982 by American Association for the Advancement of Science

articles

Role of serotonergic input in the regulation of the beta-adrenergic receptor-coupled adenylate cyclase system

A Janowsky, F Okada, DH Manier, CD Applegate, F Sulser, and LR Steranka

The action of desipramine on the norepinephrine-sensitive adenylate cyclase system and the density of beta-adrenergic receptors in rat cortex was studied after selective lesioning of serotonergic neurons with 5,7-dihydroxytryptamine. In animals with lesions desipramine failed to reduce the density of beta-adrenoceptors but decreased the response of adenosine 3',5'-monophosphate to isoproterenol and norepinephrine to the same degree as in animals without lesions. The results demonstrate a functional linkage between serotonergic and noradrenergic systems in the rat cortex, with beta-adrenergic receptors and neurohormonal sensitivity of the adenosine 3',5'-monophosphate-generating system being under separate regulatory control.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Monoamine Neurotransmitter Interactions and the Prediction of Antidepressant Response.
J. K. Hsiao, H. Agren, J. J. Bartko, M. V. Rudorfer, M. Linnoila, and W. Z. Potter (1987)
Arch Gen Psychiatry 44, 1078-1083
   Abstract »    PDF »
Selective Antidepressants and Cerebrospinal Fluid: Lack of Specificity on Norepinephrine and Serotonin Metabolites.
W. Z. Potter, M. Scheinin, R. N. Golden, M. V. Rudorfer, R. W. Cowdry, H. M. Calil, R. J. Ross, and M. Linnoila (1985)
Arch Gen Psychiatry 42, 1171-1177
   Abstract »    PDF »
A strong influence of serotonin axons on beta-adrenergic receptors in rat brain.
C. Stockmeier, A. Martino, and K. Kellar (1985)
Science 230, 323-325
   Abstract »    PDF »


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