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Science 19 November 1982:
Vol. 218. no. 4574, pp. 810 - 812
DOI: 10.1126/science.7134978
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Articles

Science, Vol 218, Issue 4574, 810-812
Copyright © 1982 by American Association for the Advancement of Science

articles

Synchronous neural afterdischarges in rat hippocampal slices without active chemical synapses

CP Taylor and FE Dudek

Extracellular field potential and intracellular recordings from neurons in rat hippocampus show that, even with synaptic transmission blocked, antidromic electrical stimuli can trigger afterdischarges of up to 9 seconds duration; during these discharges action potentials of a single neuron were synchronized with extracellularly recorded population spikes. Apparently mechanisms other than recurrent chemical synapses can synchronize and recruit epileptiform events. Measurements of transmembrane potential indicate that transient extracellular electrical fields (ephaptic interactions) contribute to the observed synchrony; electrotonic coupling and changes in the concentration of extracellular ions may also contribute.


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