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Science 12 November 1982:
Vol. 218. no. 4573, pp. 682 - 684
DOI: 10.1126/science.7134965
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Articles

Science, Vol 218, Issue 4573, 682-684
Copyright © 1982 by American Association for the Advancement of Science

articles

Sensitivity to carcinogenesis in nude mice: skin tumors caused by transplacental exposure to ethylnitrosourea

LM Anderson, K Last-Barney, and JM Budinger

Female athymic nude mice and their phenotypically normal littermates were exposed transplacentally to ethylnitrosourea. Skin tumors (papillomas and sebaceous adenomas) developed on the nude mice with an almost tenfold greater incidence than on their haired littermates. Skin tumors were also induced on nude mice but not haired controls by direct intraperitoneal treatment with ethylnitrosourea. These results indicate that nude mice have higher than normal susceptibility to carcinogenesis under some circumstances.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)