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Science 5 November 1982:
Vol. 218. no. 4572, pp. 585 - 587
DOI: 10.1126/science.6812220
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Articles

Science, Vol 218, Issue 4572, 585-587
Copyright © 1982 by American Association for the Advancement of Science

articles

Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly

R Guillemin, P Brazeau, P Bohlen, F Esch, N Ling, and WB Wehrenberg

A 44 amino acid peptide with growth hormone-releasing activity has been isolated from a human tumor of the pancreas that had caused acromegaly. The primary structure of the tumor-derived peptide is H-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser- Ala- Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Ar g-Gly -Ala-Arg-Ala-Arg-Leu-NH2. The synthetic replicate has full biological activity in vitro and in vivo specifically to stimulate the secretion of immunoreactive growth hormone. The tumor-derived peptide is identical in biological activity and similar in physiochemical properties to the still uncharacterized growth hormone-releasing factor present in extracts of hypothalamic tissues.


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