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Science 5 November 1982:
Vol. 218. no. 4572, pp. 578 - 580
DOI: 10.1126/science.6896933
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Articles

Science, Vol 218, Issue 4572, 578-580
Copyright © 1982 by American Association for the Advancement of Science

articles

A pheromone influences larval development in the nematode Caenorhabditis elegans

JW Golden and DL Riddle

A Caenorhabditis-specific pheromone and the food supply influence both entry into and exit from a developmentally arrested juvenile stage called the dauer larva. The pheromone increases the frequency of dauer larva formation and inhibits recovery but does not affect adult behavior such as chemotaxis and egg laying. The fatty acid--like pheromone has been partially purified and characterized by a new bioassay. If similar developmental control mechanisms are used by parasitic nematodes, such mechanisms might be exploited to develop highly selective anthelmintic agents.


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