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Science 5 November 1982:
Vol. 218. no. 4572, pp. 571 - 573
DOI: 10.1126/science.6981847

Articles

Science, Vol 218, Issue 4572, 571-573
Copyright © 1982 by American Association for the Advancement of Science


articles

A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia

VS Kalyanaraman, MG Sarngadharan, M Robert-Guroff, I Miyoshi, D Golde, and RC Gallo

Human T-cell leukemia virus (HTLV) is a human type-C RNA tumor virus (retrovirus) previously identified in and isolated from several patients with T-cell leukemias or lymphomas. The known virus isolates from the United States and Japan are closely related and are found in adults with an acute malignancy of mature T cells. A related retrovirus has been found in a patient (Mo) with a somewhat different disease (a T-cell variant of relatively benign hairy cell leukemia). Serum from Mo contains antibodies to the major internal core protein (p24) of HTLV. A T-cell line established from the spleen of Mo expresses HTLV antigens. However, HTLV from Mo is significantly different from all previous HTLV isolates in immunological cross-reactivity tests of p24. The usual prototype HTLV isolate is represented as HTLV-I, and the HTLV from Mo is represented as HTLV-II. Individual members of each subgroup may then be identified by subscript initials of the patient [for example, HTLV-I(CR), HTLV-I(MB), and HTLV-II(Mo)].


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U3 sequences from HTLV-I and -II LTRs confer pX protein response to a murine leukemia virus LTR.
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JAMA 257, 640-644
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HTLV x gene mutants exhibit novel transcriptional regulatory phenotypes.
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Ann Intern Med 105, 560-572
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Isolation of a new human retrovirus from West African patients with AIDS.
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Science 233, 343-346
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Prevalence of Antibodies to HTLV-I, -II, and -III in Intravenous Drug Abusers From an AIDS Endemic Region.
M. Robert-Guroff, S. H. Weiss, J. A. Giron, A. M. Jennings, H. M. Ginzburg, I. B. Margolis, W. A. Blattner, and R. C. Gallo (1986)
JAMA 255, 3133-3137
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Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression.
W. Greene, W. Leonard, Y Wano, P. Svetlik, N. Peffer, J. Sodroski, C. Rosen, W. Goh, and W. Haseltine (1986)
Science 232, 877-880
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Chronic Leukemias: Oncogenes, Chromosomes, and Advances in Therapy.
R. CHAMPLIN, R. P. GALE, K. A. FOON, and D. W. GOLDE (1986)
Ann Intern Med 104, 671-688
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Functional relation between HTLV-II x and adenovirus E1A proteins in transcriptional activation.
I. Chen, A. Cann, N. Shah, and R. Gaynor (1985)
Science 230, 570-573
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Infection by the Retrovirus Associated with the Acquired Immunodeficiency Syndrome: Clinical, Biological, and Molecular Features.
J. A. LEVY, L. S. KAMINSKY, W. J. W. MORROW, K. STEIMER, P. LUCIW, D. DINA, J. HOXIE, and L. OSHIRO (1985)
Ann Intern Med 103, 694-699
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Inhibition of lymphocyte proliferation by a synthetic peptide homologous to retroviral envelope proteins.
G. Cianciolo, T. Copeland, S Oroszlan, and R Snyderman (1985)
Science 230, 453-455
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The x gene is essential for HTLV replication.
I. Chen, D. Slamon, J. Rosenblatt, N. Shah, S. Quan, and W Wachsman (1985)
Science 229, 54-58
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Trans-activator gene of human T-lymphotropic virus type III (HTLV-III).
S. Arya, C Guo, S. Josephs, and F Wong-Staal (1985)
Science 229, 69-73
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HTLV x-gene product: requirement for the env methionine initiation codon.
W Wachsman, D. Golde, P. Temple, E. Orr, S. Clark, and I. Chen (1985)
Science 228, 1534-1537
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Studies of the putative transforming protein of the type I human T-cell leukemia virus.
D. Slamon, M. Press, L. Souza, D. Murdock, M. Cline, D. Golde, J. Gasson, and I. Chen (1985)
Science 228, 1427-1430
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A transcriptional activator protein encoded by the x-lor region of the human T-cell leukemia virus.
J Sodroski, C Rosen, W. Goh, and W Haseltine (1985)
Science 228, 1430-1434
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Serologic identification and characterization of a macaque T-lymphotropic retrovirus closely related to HTLV-III.
P. Kanki, M. McLane, N. King Jr, N. Letvin, R. Hunt, P Sehgal, M. Daniel, R. Desrosiers, and M Essex (1985)
Science 228, 1199-1201
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The Acquired Immunodeficiency Syndrome: An Update.
A. S. FAUCI, H. MASUR, E. P. GELMANN, P. D. MARKHAM, B. H. HAHN, and H. C. LANE (1985)
Ann Intern Med 102, 800-813
   Abstract »    PDF »
Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III.
J. Allan, J. Coligan, F Barin, M. McLane, J. Sodroski, C. Rosen, W. Haseltine, T. Lee, and M Essex (1985)
Science 228, 1091-1094
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Human GM-CSF: molecular cloning of the complementary DNA and purification of the natural and recombinant proteins.
G. Wong, J. Witek, P. Temple, K. Wilkens, A. Leary, D. Luxenberg, S. Jones, E. Brown, R. Kay, E. Orr, et al. (1985)
Science 228, 810-815
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Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeat.
J Sodroski, C Rosen, F Wong-Staal, S. Salahuddin, M Popovic, S Arya, R. Gallo, and W. Haseltine (1985)
Science 227, 171-173
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Sequence homology and morphologic similarity of HTLV-III and visna virus, a pathogenic lentivirus.
M. Gonda, F Wong-Staal, R. Gallo, J. Clements, O Narayan, and R. Gilden (1985)
Science 227, 173-177
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Leads from the MMWR.
(1985)
JAMA 253, 21-23
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Diagnostic potential for human malignancies of bacterially produced HTLV-I envelope protein.
K. Samuel, J. Lautenberger, C. Jorcyk, S Josephs, F Wong-Staal, and T. Papas (1984)
Science 226, 1094-1097
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Alteration of T-cell functions by infection with HTLV-I or HTLV-II.
M Popovic, N Flomenberg, D. Volkman, D Mann, A. Fauci, B Dupont, and R. Gallo (1984)
Science 226, 459-462
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Expression of the 3' terminal region of human T-cell leukemia viruses.
W Wachsman, K Shimotohno, S. Clark, D. Golde, and I. Chen (1984)
Science 226, 177-179
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Antigens encoded by the 3'-terminal region of human T-cell leukemia virus: evidence for a functional gene.
T. Lee, J. Coligan, J. Sodroski, W. Haseltine, S. Salahuddin, F Wong-Staal, R. Gallo, and M Essex (1984)
Science 226, 57-61
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Identification of the putative transforming protein of the human T-cell leukemia viruses HTLV-I and HTLV-II.
D. Slamon, K Shimotohno, M. Cline, D. Golde, and I. Chen (1984)
Science 226, 61-65
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Homology of genome of AIDS-associated virus with genomes of human T-cell leukemia viruses.
S. Arya, R. Gallo, B. Hahn, G. Shaw, M Popovic, S. Salahuddin, and F Wong-Staal (1984)
Science 225, 927-930
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Lymphoma in macaques: association with virus of human T lymphotrophic family.
T Homma, P. Kanki, N. King Jr, R. Hunt, M. O'Connell, N. Letvin, M. Daniel, R. Desrosiers, C. Yang, and M Essex (1984)
Science 225, 716-718
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Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells.
J. Sodroski, C. Rosen, and W. Haseltine (1984)
Science 225, 381-385
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Structure of 3' terminal region of type II human T lymphotropic virus: evidence for new coding region.
W. Haseltine, J Sodroski, R Patarca, D Briggs, D Perkins, and F Wong-Staal (1984)
Science 225, 419-421
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Sequence of the envelope glycoprotein gene of type II human T lymphotropic virus.
J Sodroski, R Patarca, D Perkins, D Briggs, T. Lee, M Essex, J Coligan, F Wong-Staal, R. Gallo, and W. Haseltine (1984)
Science 225, 421-424
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Antibodies to the core protein of lymphadenopathy-associated virus (LAV) in patients with AIDS.
V. Kalyanaraman, C. Cabradilla, J. Getchell, R Narayanan, E. Braff, J. Chermann, F Barre-Sinoussi, L Montagnier, T. Spira, J Kaplan, et al. (1984)
Science 225, 321-323
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Proliferation of astroglia and oligodendroglia in response to human T cell-derived factors.
J. Merrill, S Kutsunai, C Mohlstrom, F Hofman, J Groopman, and D. Golde (1984)
Science 224, 1428-1430
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Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS.
M Popovic, M. Sarngadharan, E Read, and R. Gallo (1984)
Science 224, 497-500
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Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS.
R. Gallo, S. Salahuddin, M Popovic, G. Shearer, M Kaplan, B. Haynes, T. Palker, R Redfield, J Oleske, B Safai, et al. (1984)
Science 224, 500-503
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Serological analysis of a subgroup of human T-lymphotropic retroviruses (HTLV-III) associated with AIDS.
J Schupbach, M Popovic, R. Gilden, M. Gonda, M. Sarngadharan, and R. Gallo (1984)
Science 224, 503-505
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Antibodies reactive with human T-lymphotropic retroviruses (HTLV-III) in the serum of patients with AIDS.
M. Sarngadharan, M Popovic, L Bruch, J Schupbach, and R. Gallo (1984)
Science 224, 506-508
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T-Cell Lymphoproliferative Syndrome Associated with Human T-Cell Leukemia/Lymphoma Virus.
S. BRODER, P. A. BUNN Jr., E. S. JAFFE, W. BLATTNER, R. C. GALLO, F. WONG-STAAL, T. A. WALDMANN, and V. T. DeVITA Jr. (1984)
Ann Intern Med 100, 543-557
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Novel viral sequences related to human T-cell leukemia virus in T cells of a seropositive baboon.
H. Guo, F Wong-Stall, and R. Gallo (1984)
Science 223, 1195-1197
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Acquired Immunodeficiency Syndrome: Epidemiologic, Clinical, Immunologic, and Therapeutic Considerations.
A. S. FAUCI, A. M. MACHER, D. L. LONGO, H. C. LANE, A. H. ROOK, H. MASUR, and E. P. GELMANN (1984)
Ann Intern Med 100, 92-106
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Productive infection and cell-free transmission of human T-cell leukemia virus in a nonlymphoid cell line.
P Clapham, K Nagy, R Cheingsong-Popov, M Exley, and R. Weiss (1983)
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Human T-Cell Leukemia-Lymphoma Virus and Adult T-Cell Leukemia.
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   Abstract »    PDF »
Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS).
R. Gallo, P. Sarin, E. Gelmann, M Robert-Guroff, E Richardson, V. Kalyanaraman, D Mann, G. Sidhu, R. Stahl, S Zolla-Pazner, et al. (1983)
Science 220, 865-867
   Abstract »    PDF »
Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).
F Barre-Sinoussi, J. Chermann, F Rey, M. Nugeyre, S Chamaret, J Gruest, C Dauguet, C Axler-Blin, F Vezinet-Brun, C Rouzioux, et al. (1983)
Science 220, 868-871
   Abstract »    PDF »
Isolation and transmission of human retrovirus (human t-cell leukemia virus).
M Popovic, P. Sarin, M Robert-Gurroff, V. Kalyanaraman, D Mann, J Minowada, and R. Gallo (1983)
Science 219, 856-859
   Abstract »    PDF »
Drug firm and UC settle interferon suit.
B. Culliton (1983)
Science 219, 372
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Science. ISSN 0036-8075 (print), 1095-9203 (online)