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Science 5 November 1982: Vol. 218. no. 4572, pp. 571 - 573 DOI: 10.1126/science.6981847
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Articles
Science, Vol 218, Issue 4572, 571-573
Copyright © 1982 by American Association for the Advancement of Science
A new subtype of human T-cell leukemia virus (HTLV-II) associated with a T-cell variant of hairy cell leukemia
VS Kalyanaraman,
MG Sarngadharan,
M Robert-Guroff,
I Miyoshi,
D Golde,
and
RC Gallo
Human T-cell leukemia virus (HTLV) is a human type-C RNA tumor virus (retrovirus) previously identified in and isolated from several patients with T-cell leukemias or lymphomas. The known virus isolates from the United States and Japan are closely related and are found in adults with an acute malignancy of mature T cells. A related retrovirus has been found in a patient (Mo) with a somewhat different disease (a T-cell variant of relatively benign hairy cell leukemia). Serum from Mo contains antibodies to the major internal core protein (p24) of HTLV. A T-cell line established from the spleen of Mo expresses HTLV antigens. However, HTLV from Mo is significantly different from all previous HTLV isolates in immunological cross-reactivity tests of p24. The usual prototype HTLV isolate is represented as HTLV-I, and the HTLV from Mo is represented as HTLV-II. Individual members of each subgroup may then be identified by subscript initials of the patient [for example, HTLV-I(CR), HTLV-I(MB), and HTLV-II(Mo)].
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- Acquired Immunodeficiency Syndrome: Epidemiologic, Clinical, Immunologic, and Therapeutic Considerations.
- A. S. FAUCI, A. M. MACHER, D. L. LONGO, H. C. LANE, A. H. ROOK, H. MASUR, and E. P. GELMANN (1984)
Ann Intern Med
100, 92-106
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- Productive infection and cell-free transmission of human T-cell leukemia virus in a nonlymphoid cell line.
- P Clapham, K Nagy, R Cheingsong-Popov, M Exley, and R. Weiss (1983)
Science
222, 1125-1127
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- The Human T-Cell Leukemia-Lymphoma Virus in the Southeastern United States.
- D. W. Blayney, W. A. Blattner, M. Robert-Guroff, E. S. Jaffe, R. I. Fisher, P. A. Bunn Jr, M. G. Patton, H. R. Rarick, and R. C. Gallo (1983)
JAMA
250, 1048-1052
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- Human T-Cell Leukemia-Lymphoma Virus and Adult T-Cell Leukemia.
- W. A. Blattner, K. Takatsuki, and R. C. Gallo (1983)
JAMA
250, 1074-1080
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- Antibodies to cell membrane antigens associated with human T-cell leukemia virus in patients with AIDS.
- M Essex, M. McLane, T. Lee, L Falk, C. Howe, J. Mullins, C Cabradilla, and D. Francis (1983)
Science
220, 859-862
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- Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS).
- R. Gallo, P. Sarin, E. Gelmann, M Robert-Guroff, E Richardson, V. Kalyanaraman, D Mann, G. Sidhu, R. Stahl, S Zolla-Pazner, et al. (1983)
Science
220, 865-867
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- Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).
- F Barre-Sinoussi, J. Chermann, F Rey, M. Nugeyre, S Chamaret, J Gruest, C Dauguet, C Axler-Blin, F Vezinet-Brun, C Rouzioux, et al. (1983)
Science
220, 868-871
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- Isolation and transmission of human retrovirus (human t-cell leukemia virus).
- M Popovic, P. Sarin, M Robert-Gurroff, V. Kalyanaraman, D Mann, J Minowada, and R. Gallo (1983)
Science
219, 856-859
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- Drug firm and UC settle interferon suit.
- B. Culliton (1983)
Science
219, 372
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