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Science 29 October 1982:
Vol. 218. no. 4571, pp. 491 - 492
DOI: 10.1126/science.6889765
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Articles

Science, Vol 218, Issue 4571, 491-492
Copyright © 1982 by American Association for the Advancement of Science

articles

Pavlovian conditional tolerance to haloperidol catalepsy: evidence of dynamic adaptation in the dopaminergic system

CX Poulos and R Hinson

An experiment with rats has demonstrated that Pavlovian conditioning factors determine the occurrence of tolerance to haloperidol catalepsy. Rats exhibited tolerance only in the environment previously associated with the drug. Previous research involving receptor binding techniques implicated an increase in the number of brain dopamine receptors as the mediator of neuroleptic tolerance. The present findings demonstrate that this change, by itself, cannot account for the conditional occurrence of such tolerance.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Procedures affecting maintenance and loss of tolerance to amphetamine-induced anorexia and cross-tolerance to haloperidol-induced catalepsy.
A. Streather and R.E. Hinson (1991)
J Psychopharmacol 5, 65-71
   Abstract »    PDF »
Haloperidol-induced catalepsy is modulated by the development of tolerance to amphetamine-induced anorexia.
A. Streather and R. E. Hinson (1990)
J Psychopharmacol 4, 19-28
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)