Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 29 October 1982:
Vol. 218. no. 4571, pp. 483 - 485
DOI: 10.1126/science.7123248
Prev | Table of Contents | Next

Articles

Science, Vol 218, Issue 4571, 483-485
Copyright © 1982 by American Association for the Advancement of Science

articles

Type A behavior and elevated physiological and neuroendocrine responses to cognitive tasks

RB Williams Jr, JD Lane, CM Kuhn, W Melosh, AD White, and SM Schanberg

Qualitatively distinct patterns of cardiovascular and neuroendocrine responses were observed in male college students during mental work and during sensory intake task performance. During mental work, Type A (coronary-prone) subjects showed greater muscle vasodilatation and more enhanced secretion of norepinephrine, epinephrine, and cortisol than Type B subjects. During sensory intake, Type A hyperresponsivity was found for testosterone and, among those subjects with a positive family history of hypertension, for cortisol. As a demonstration of combined cardiovascular, sympathetic nervous system, and neuroendocrine hyperresponsivity to specific cognitive tasks in Type A subjects, this study breaks ground in the search for mechanisms mediating the increased coronary disease risk among Type A persons.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
An Exploratory Study of Subgrouping of Patients With Functional Somatic Syndrome Based on the Psychophysiological Stress Response: Its Relationship With Moods and Subjective Variables.
K. Kanbara, M. Fukunaga, H. Mutsuura, H. Takeuchi, K. Kitamura, and Y. Nakai (2007)
Psychosom Med 69, 158-165
   Abstract »    Full Text »    PDF »
Hopelessness Is Associated With Decreased Heart Rate Variability During Championship Chess Games.
A. M. Schwarz, H. Schachinger, R. H. Adler, and S. M. Goetz (2003)
Psychosom Med 65, 658-661
   Abstract »    Full Text »    PDF »
Topical Fundus Pulsation Measurement in Patients With Active Central Serous Chorioretinopathy.
M. Tittl, E. Polska, K. Kircher, A. Kruger, N. Maar, M. Stur, and L. Schmetterer (2003)
Arch Ophthalmol 121, 975-978
   Abstract »    Full Text »    PDF »
Hostility, Gender, and Cardiac Autonomic Control.
R. P. Sloan, E. Bagiella, P. A. Shapiro, J. P. Kuhl, D. Chernikhova, J. Berg, and M. M. Myers (2001)
Psychosom Med 63, 434-440
   Abstract »    Full Text »    PDF »
Cardiac Autonomic Control Buffers Blood Pressure Variability Responses to Challenge: A Psychophysiologic Model of Coronary Artery Disease.
R. P. Sloan, P. A. Shapiro, E. Bagiella, M. M. Myers, and J. M. Gorman (1999)
Psychosom Med 61, 58-68
   Abstract »    Full Text »    PDF »
Exaggerated Reactivity to Mental Stress Is Associated With Exercise-Induced Myocardial Ischemia in an Asymptomatic High-Risk Population.
B. G. Kral, L. C. Becker, R. S. Blumenthal, T. Aversano, L. A. Fleisher, R. M. Yook, and D. M. Becker (1997)
Circulation 96, 4246-4253
   Abstract »    Full Text »
Endogenous cortisol profile in patients with central serous chorioretinopathy.
S P Garg, T. Dada, D. Talwar, and N R Biswas (1997)
Br J Ophthalmol 81, 962-964
   Abstract »    Full Text »    PDF »
Glucocorticoids Stimulate Cholesteryl Ester Formation in Human Smooth Muscle Cells.
I. E. Petrichenko, D. Daret, G. V. Kolpakova, Y. A. Shakhov, and J. Larrue (1997)
Arterioscler Thromb Vasc Biol 17, 1143-1151
   Abstract »    Full Text »
Vital Exhaustion, Anger Expression, and Pituitary and Adrenocortical Hormones : Implications for the Insulin Resistance Syndrome.
L. Keltikangas-Jarvinen, K. Raikkonen, A. Hautanen, and H. Adlercreutz (1996)
Arterioscler Thromb Vasc Biol 16, 275-280
   Abstract »    Full Text »
Effects of Dexamethasone on the Synthesis, Degradation, and Secretion of Apolipoprotein B in Cultured Rat Hepatocytes.
C.-N. Wang, R. S. McLeod, Z. Yao, and D. N. Brindley (1995)
Arterioscler Thromb Vasc Biol 15, 1481-1491
   Abstract »    Full Text »
Central Serous Chorioretinopathy in Endogenous Hypercortisolism.
E. A. Bouzas, M. H. Scott, G. Mastorakos, G. P. Chrousos, and M. I. Kaiser-Kupfer (1993)
Arch Ophthalmol 111, 1229-1233
   Abstract »    PDF »
Effect of Innervation on Heart Rate Response to Mental Stress.
P. A. Shapiro, R. P. Sloan, E. M. Horn, M. M. Myers, and J. M. Gorman (1993)
Arch Gen Psychiatry 50, 275-279
   Abstract »    PDF »
Somatic Manifestations in Women With Generalized Anxiety Disorder: Psychophysiological Responses to Psychological Stress.
R. Hoehn-Saric, D. R. McLeod, and W. D. Zimmerli (1989)
Arch Gen Psychiatry 46, 1113-1119
   Abstract »    PDF »
Social stress and atherosclerosis in normocholesterolemic monkeys.
Kaplan JR, S. Manuck, T. Clarkson, F. Lusso, D. Taub, and E. Miller (1983)
Science 220, 733-735
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)