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Science 29 October 1982:
Vol. 218. no. 4571, pp. 483 - 485
DOI: 10.1126/science.7123248
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Articles

Science, Vol 218, Issue 4571, 483-485
Copyright © 1982 by American Association for the Advancement of Science

articles

Type A behavior and elevated physiological and neuroendocrine responses to cognitive tasks

RB Williams Jr, JD Lane, CM Kuhn, W Melosh, AD White, and SM Schanberg

Qualitatively distinct patterns of cardiovascular and neuroendocrine responses were observed in male college students during mental work and during sensory intake task performance. During mental work, Type A (coronary-prone) subjects showed greater muscle vasodilatation and more enhanced secretion of norepinephrine, epinephrine, and cortisol than Type B subjects. During sensory intake, Type A hyperresponsivity was found for testosterone and, among those subjects with a positive family history of hypertension, for cortisol. As a demonstration of combined cardiovascular, sympathetic nervous system, and neuroendocrine hyperresponsivity to specific cognitive tasks in Type A subjects, this study breaks ground in the search for mechanisms mediating the increased coronary disease risk among Type A persons.


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