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Science 29 October 1982:
Vol. 218. no. 4571, pp. 475 - 477
DOI: 10.1126/science.6981846
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Articles

Science, Vol 218, Issue 4571, 475-477
Copyright © 1982 by American Association for the Advancement of Science

articles

Placental mononuclear phagocytes as a source of interleukin-1

A Flynn, JH Finke, and ML Hilfiker

Mouse and human placental tissue contains a large number of mononuclear phagocytes. These cells, isolated from placenta, were shown to produce the multifaceted immune factor interleukin-1. Activity in the supernatants of 48-hour mononuclear phagocyte cultures was associated with a 12,000- to 18,000-dalton protein, consistent with known interleukin-1 characteristics. Stimulation of phagocytosis with latex beads increased the production and release of interleukin-1 from these placental cells, which may be a useful source of this protein.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)