Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 29 October 1982:
Vol. 218. no. 4571, pp. 471 - 473
DOI: 10.1126/science.6981845
Prev | Table of Contents | Next

Articles

Science, Vol 218, Issue 4571, 471-473
Copyright © 1982 by American Association for the Advancement of Science

articles

Surface structures involved in target recognition by human cytotoxic T lymphocytes

SC Meuer, RE Hussey, JC Hodgdon, T Hercend, SF Schlossman, and EL Reinherz

Cloned human cytotoxic T lymphocytes and monoclonal antibodies inhibiting their function (anti-T3A, anti-T4A, and anti-T8A) were used to elucidate the role of T cell surface glycoproteins in cell-mediated lympholysis involving individual classes of gene products of the major histocompatibility complex on target cells. The results indicate that several surface molecules are required for specific target recognition: T3 and T4 on T4+ cytotoxic T lymphocytes and T3 and T8 on T8+ cytotoxic T lymphocytes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Genetically Modified HLA Class I Molecules Able to Inhibit Human NK Cells Without Provoking Alloreactive CD8+ CTLs.
A. Sharland, A. Patel, J. H. Lee, A. E. Cestra, S. Saidman, and G. L. Waneck (2002)
J. Immunol. 168, 3266-3274
   Abstract »    Full Text »    PDF »
Activation Requirements, Lytic Mechanism, and Development of a Novel Anti-CD8-Resistant CTL Population.
S. A. McCarthy, M. S. Mainwaring, D. S. Dougall, and E. S. Lamouse-Smith (1998)
J. Immunol. 160, 2715-2724
   Abstract »    Full Text »    PDF »
Halo Congenital Nevus Undergoing Spontaneous Regression: Involvement of T-Cell Immunity in Involution and Presence of Circulating Anti--Nevus Cell IgM Antibodies.
Y. Tokura, K. Yamanaka, H. Wakita, S. Kurokawa, D. Horiguchi, A. Usui, S. Sayama, and M. Takigawa (1994)
Arch Dermatol 130, 1036-1041
   Abstract »    PDF »
The Biology of Human CD2.
E.L. Reinherz, H.-C. Chang, L.K. Clayton, P. Gardner, F.D. Howard, S. Koyasu, Y.-J. Jin, P. Moingeon, and P.H. Sayre (1989)
Cold Spring Harb Symp Quant Biol 54, 611-625
   Abstract »    PDF »
Alloantigen recognition is preceded by nonspecific adhesion of cytotoxic T cells and target cells.
H Spits, W van Schooten, H Keizer, G van Seventer, M van de Rijn, C Terhorst, and J. de Vries (1986)
Science 232, 403-405
   Abstract »    PDF »
Analysis of T-cell receptor gene rearrangement and expression in human natural killer clones.
J Ritz, T. Campen, R. Schmidt, H. Royer, T Hercend, R. Hussey, and E. Reinherz (1985)
Science 228, 1540-1543
   Abstract »    PDF »
T-Cell Lymphoproliferative Syndrome Associated with Human T-Cell Leukemia/Lymphoma Virus.
S. BRODER, P. A. BUNN Jr., E. S. JAFFE, W. BLATTNER, R. C. GALLO, F. WONG-STAAL, T. A. WALDMANN, and V. T. DeVITA Jr. (1984)
Ann Intern Med 100, 543-557
   Abstract »    PDF »
Identification of the receptor for antigen and major histocompatibility complex on human inducer T lymphocytes.
S. Meuer, D. Cooper, J. Hodgdon, R. Hussey, K. Fitzgerald, S. Schlossman, and E. Reinherz (1983)
Science 222, 1239-1242
   Abstract »    PDF »
Neural Surface Antigens during Nervous System Development.
C. Goridis, H. Deagostini-Bazin, M. Hirn, M.-R. Hirsch, G. Rougon, R. Sadoul, O.K. Langley, G. Gombos, and J. Finne (1983)
Cold Spring Harb Symp Quant Biol 48, 527-537
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)